ReviewThe Journal of biological chemistry2011
Tearin' up my heart: proteolysis in the cardiac sarcomere.
Review in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 87 citations in OpenAlex.
- The Pathophysiology of Cardiac Troponin Release and the Various Circulating Cardiac Troponin Forms-Potential Clinical Implications.Journal of clinical medicine · 2025Review
- Circadian regulation of cardiac muscle function and protein degradation.Chronobiology international · 2023Article
- Protein Quality Control at the Sarcomere: Titin Protection and Turnover and Implications for Disease Development.Frontiers in physiology · 2022Review
- E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system.Scientific reports · 2021Article
- Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy.The Biochemical journal · 2021Article
- Live imaging of adult zebrafish cardiomyocyte proliferation ex vivo.Development (Cambridge, England) · 2021Article
- Calpain-Mediated Mitochondrial Damage: An Emerging Mechanism Contributing to Cardiac Disease.Cells · 2021Review
- The Role of HECT-Type E3 Ligase in the Development of Cardiac Disease.International journal of molecular sciences · 2021Review
- Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin.Nature communications · 2020Article
- Generation of MuRF-GFP transgenic zebrafish models for investigating murf gene expression and protein localization in Smyd1b and Hsp90α1 knockdown embryos.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2020Article
- Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases.International journal of molecular sciences · 2020Review
- Distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers.American journal of physiology. Cell physiology · 2019Article
- Irreversible oxidative post-translational modifications in heart disease.Expert review of proteomics · 2019Review
- Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.Nature reviews. Cardiology · 2018Review
- Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis.Developmental biology · 2018Article
- UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.Nature communications · 2018Article
- Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation.Free radical biology & medicine · 2018Article
- EPG5-Related Vici Syndrome: A Primary Defect of Autophagic Regulation with an Emerging Phenotype Overlapping with Mitochondrial Disorders.JIMD reports · 2018Article
- Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes.Scientific reports · 2017Article
- Ischemia/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists.Mediators of inflammation · 2017 · on this mapReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Proteolysis within the cardiac sarcomere is a constantly evolving area of research. Three major pathways of proteolysis have been identified as being active within the cardiac sarcomere, namely the ubiquitin-proteasome system, autophagy, and the calpain system. The role of ubiquitin-proteasome system-mediated proteolysis in cardiovascular health and disease has been known for some time; however, it is now apparent that other proteolytic systems also aid in the stabilization of cardiac sarcomere structure and function. This minireview focuses on the individual as well as cooperative involvement of each of these three major pathways of proteolysis within the cardiac sarcomere.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.