Evidence map›Paper›PMID 21257753›Full record

ReviewThe Journal of biological chemistry2011

Redox signaling and cardiac sarcomeres.

Marius P Sumandea, Susan F Steinberg

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Indirect evidence that anoxia exposure and cold acclimation alter transarcolemmal CaComparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2021
    Article
  5. Article
  6. Article
  7. Screening forTheranostics · 2020
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
  14. Article
  15. Hydrogen Sulfide and Cellular Redox Homeostasis.Oxidative medicine and cellular longevity · 2016
    Review
  16. Review
  17. Review
  18. Redox-sensitive residue in the actin-binding interface of myosin.Biochemical and biophysical research communications · 2014
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Marius P SumandeaDepartment of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, Kentucky 40536, USA. mariussumandea@uky.edu
Susan F Steinberg
Columbia University · USUniversity of Kentucky · US

Funding

Protein kinase C-delta actions in cardiomyocytesR01HL077860 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEINBERG, SUSAN F · 2004 to 2013
$3.4M
Oxidative Stress and Myocardial FunctionR03AG032009 · NIA · UNIVERSITY OF KENTUCKY · PI SUMANDEA, MARIUS P · 2009 to 2010
$122k
NHLBI NIH HHS HL77860NHLBI NIH HHS R01 HL077860NIA NIH HHS AG032009NIA NIH HHS R03 AG032009
6 · The paper itself

Abstract

Oxidative stress is common in many clinically important cardiac disorders, including ischemia/reperfusion, diabetes, and hypertensive heart disease. Oxidative stress leads to derangements in pump function due to changes in the expression or function of proteins that regulate intracellular Ca(2+) homeostasis. There is growing evidence that the cardiodepressant actions of reactive oxygen species (ROS) also are attributable to ROS-dependent signaling events in the sarcomere. This minireview focuses on myofilament protein post-translational modifications induced by ROS or ROS-activated signaling enzymes that regulate cardiac contractility.

Indexed as

Myocardial ContractionOxidative StressSignal TransductionAnimalsCalciumHeart DiseasesHomeostasisHumansMyocardiumReactive Oxygen SpeciesSarcomeresCalciumReactive Oxygen Species

Identifiers

PMID21257753
PMCPMC3060545
OpenAlexW1978042419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.