ArticleThe Journal of biological chemistry2011
Inflammation of the hypothalamus leads to defective pancreatic islet function.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Diabetic Encephalopathy: Role of Oxidative and Nitrosative Factors in Type 2 Diabetes.Indian journal of clinical biochemistry : IJCB · 2024Review
- Dissecting the Brain/Islet Axis in Metabesity.Genes · 2019Review
- Hypothalamic oxidative stress and inflammation, and peripheral glucose homeostasis in Sprague-Dawley rat offspring exposed to maternal and postnatal chocolate and soft drink.Nutrition & diabetes · 2018Article
- Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain.Journal of visualized experiments : JoVE · 2018Article
- Inflammatory Links Between High Fat Diets and Diseases.Frontiers in immunology · 2018Review
- Microglia activation due to obesity programs metabolic failure leading to type two diabetes.Nutrition & diabetes · 2017Review
- Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity.Journal of neuroinflammation · 2017Article
- Hypothalamic inflammation in obesity and metabolic disease.The Journal of clinical investigation · 2017Review
- Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals.Frontiers in endocrinology · 2017Review
- Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?Frontiers in endocrinology · 2017Article
- RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat.Scientific reports · 2016Article
- Article
- Hypothalamic inflammation and gliosis in obesity.Current opinion in endocrinology, diabetes, and obesity · 2015Review
- Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice.American journal of physiology. Endocrinology and metabolism · 2015Article
- Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer's type dementia.European journal of nutrition · 2015Article
- Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response.Nature medicine · 2014Article
- An overview of the identification and management of the metabolic syndrome in chiropractic practice.Journal of chiropractic medicine · 2014Article
- Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes.Diabetologia · 2014Review
- Identification of optimal reference genes for RT-qPCR in the rat hypothalamus and intestine for the study of obesity.International journal of obesity (2005) · 2014Article
Corrections and comments
- Retraction · 2016-11-22Duplication of/in Image · Error in Image · · Lício A. Velloso 'takes all responsibility for the withdrawal'
- Retracted
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus results from the complex association of insulin resistance and pancreatic β-cell failure. Obesity is the main risk factor for type 2 diabetes mellitus, and recent studies have shown that, in diet-induced obesity, the hypothalamus becomes inflamed and dysfunctional, resulting in the loss of the perfect coupling between caloric intake and energy expenditure. Because pancreatic β-cell function is, in part, under the control of the autonomic nervous system, we evaluated the role of hypothalamic inflammation in pancreatic islet function. In diet-induced obesity, the earliest markers of hypothalamic inflammation are present at 8 weeks after the beginning of the high fat diet; similarly, the loss of the first phase of insulin secretion is detected at the same time point and is restored following sympathectomy. Intracerebroventricular injection of a low dose of tumor necrosis factor α leads to a dysfunctional increase in insulin secretion and activates the expression of a number of markers of apoptosis in pancreatic islets. In addition, the injection of stearic acid intracerebroventricularly, which leads to hypothalamic inflammation through the activation of tau-like receptor-4 and endoplasmic reticulum stress, produces an impairment of insulin secretion, accompanied by increased expression of markers of apoptosis. The defective insulin secretion, in this case, is partially dependent on sympathetic signal-induced peroxisome proliferator receptor-γ coactivator Δα and uncoupling protein-2 expression and is restored after sympathectomy or following PGC1α expression inhibition by an antisense oligonucleotide. Thus, the autonomic signals generated in concert with hypothalamic inflammation can impair pancreatic islet function, a phenomenon that may explain the early link between obesity and defective insulin secretion.
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