ArticleThe Journal of infectious diseases2011
Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa.Science translational medicine · 2019Trial
- Enterocyte Autoantibodies (GECAs) and HLA: Their Relationship with HIV Infection Pathogenesis.International journal of molecular sciences · 2026Review
- Impact of TNF-α (- 308G>A and - 857 C>T) promoter variants on susceptibility to chronic hepatitis B virus infection in a cohort of Mauritanian patients: pilot study.BMC microbiology · 2026Article
- Pathogen Adaptation of HLA Alleles and Its Correlation with Autoimmune Diseases in the Han Chinese.Genomics, proteomics & bioinformatics · 2025Article
- Deciphering the host genetic factors conferring susceptibility to severe COVID-19 using exome sequencing.Genes and immunity · 2024Article
- A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.Nature genetics · 2021Article
- Genetic and epigenetic factors associated with increased severity of Covid-19.Cell biology international · 2021Review
- Association of HLA Genotype With T-Cell Activation in Human Immunodeficiency Virus (HIV) and HIV/Hepatitis C Virus-Coinfected Women.The Journal of infectious diseases · 2020Article
- Possible clearance of transfusion-acquiredJournal of virus eradication · 2019Article
- Host genetic variation and HIV disease: from mapping to mechanism.Immunogenetics · 2017Review
- Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles.AIDS (London, England) · 2017Article
- HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II TetramerJournal of virology · 2017Article
- Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?Frontiers in immunology · 2017Review
- Review
- Innate and Adaptive Immune Regulation During Chronic Viral Infections.Annual review of virology · 2015Review
- HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition.Science translational medicine · 2015Article
- Associations of host genetic variants on CD4⁺ lymphocyte count and plasma HIV-1 RNA in antiretroviral naïve children.The Pediatric infectious disease journal · 2014Article
- Association of HLA-DRB1-restricted CD4⁺ T cell responses with HIV immune control.Nature medicine · 2013Article
- Immunogenetics of HIV disease.Immunological reviews · 2013Review
- Innate and Adaptive Immunity in Long-Term Non-Progression in HIV Disease.Frontiers in immunology · 2013Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe HLA class II molecules play a central role in the generation of human immunodeficiency virus (HIV)-specific CD4(+) T-helper cells, which are critical for the induction of cytotoxic CD8(+) T cell responses. However, little is known about the impact of HLA class II alleles on HIV disease progression.
methodsIn this study we investigated the effect of HLA class II alleles on HIV disease outcome and HIV-specific T cell responses in a cohort of 426 antiretroviral therapy-naive, HIV-1 clade C-infected, predominantly female black South Africans.
resultsThe HLA class II allele DRB1*1303 was independently associated with lower plasma viral loads in this population (P = .02), an association that was confirmed in a second cohort of 1436 untreated, HIV-1 clade B-infected, male European Americans, suggesting that DRB1*1303-mediated protection is independent of ethnicity, sex, and viral clade. Interestingly, DRB1*1303 carriage was not associated with an increased frequency of interferon (IFN) γ-positive HIV-specific CD4(+) T cell responses.
conclusionsThese data demonstrate the independent effect of an HLA class II allele, DRB1*1303, on HIV disease progression, in the absence of increased IFN-γ-positive HIV-specific CD4(+) T cell frequencies, suggesting that the protective activity of DRB1*1303 may be mediated via an alternative mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.