ArticleAmerican journal of physiology. Lung cellular and molecular physiology2011
Endocytic response of type I alveolar epithelial cells to hypertonic stress.
Article in American journal of physiology. Lung cellular and molecular physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Aging-Associated Molecular Changes in Human Alveolar Type I Cells.Journal of respiratory biology and translational medicine · 2024Article
- SLC22A11 Inserts the Uremic Toxins Indoxyl Sulfate and P-Cresol Sulfate into the Plasma Membrane.International journal of molecular sciences · 2023Article
- Article
- Polyethylenimine-Conjugated Hydroxyethyl Cellulose for Doxorubicin/Bcl-2 siRNA Co-Delivery Systems.Pharmaceutics · 2023Article
- Lysosomal solute and water transport.The Journal of cell biology · 2022Review
- Both Clathrin-Mediated and Membrane Microdomain-Associated Endocytosis Contribute to the Cellular Adaptation to Hyperosmotic Stress inInternational journal of molecular sciences · 2021Article
- Article
- Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study.Intensive care medicine experimental · 2021Article
- Highly Osmotic Oxidized Sucrose-Crosslinked Polyethylenimine for Gene Delivery Systems.Pharmaceutics · 2021Article
- Endocytosis in the adaptation to cellular stress.Cell stress · 2020Review
- TRIM72 promotes alveolar epithelial cell membrane repair and ameliorates lung fibrosis.Respiratory research · 2020Article
- A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure.Journal of cellular and molecular medicine · 2020Article
- Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors.Journal of nanobiotechnology · 2020Article
- Hypercapnia Alters Alveolar Epithelial Repair by a pH-Dependent and Adenylate Cyclase-Mediated Mechanism.Scientific reports · 2019Article
- Inhaled TRIM72 Protein Protects Ventilation Injury to the Lung through Injury-guided Cell Repair.American journal of respiratory cell and molecular biology · 2018Article
- Endocytic Uptake, Transport and Macromolecular Interactions of Anionic PAMAM Dendrimers within Lung Tissue.Pharmaceutical research · 2017Article
- Plasma membrane wounding and repair in pulmonary diseases.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- TRIM72 modulates caveolar endocytosis in repair of lung cells.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Physical principles of membrane remodelling during cell mechanoadaptation.Nature communications · 2015Article
- Critical determinants of uptake and translocation of nanoparticles by the human pulmonary alveolar epithelium.ACS nano · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We present plasma membrane (PM) internalization responses of type I alveolar epithelial cells to a 50 mosmol/l increase in tonicity. Our research is motivated by interest in ATI repair, for which endocytic retrieval of PM appears to be critical. We validated pharmacological and molecular tools to dissect the endocytic machinery of these cells and used these tools to test the hypothesis that osmotic stress triggers a pathway-specific internalization of PM domains. Validation experiments confirmed the fluorescent analogs of lactosyl-ceramide, transferrin, and dextran as pathway-specific cargo of caveolar, clathrin, and fluid-phase uptake, respectively. Pulse-chase experiments indicate that hypertonic exposure causes a downregulation of clathrin and fluid-phase endocytosis while stimulating caveolar endocytosis. The tonicity-mediated increase in caveolar endocytosis was associated with the translocation of caveolin-1 from the PM and was absent in cells that had been transfected with dominant-negative dynamin constructs. In separate experiments we show that hypertonic exposure increases the probability of PM wound repair following micropuncture from 82 ± 4 to 94 ± 2% (P < 0.01) and that this effect depends on Src pathway activation-mediated caveolar endocytosis. The therapeutic and biological implications of our findings are discussed.
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