ReviewHearing research2011
Dissecting the molecular basis of organ of Corti development: Where are we now?
Review in Hearing research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Targeted cell interconversions reveal inner hair cell control of organ of Corti cytoarchitecture.Science advances · 2025Article
- Histamine H3 Receptor Antagonists Influence the Directional Growth of Type II Spiral Ganglion Neurites Within the Developing Cochlea of C57BL/6 Mice.Neurochemical research · 2025Article
- Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation.Frontiers in neurology · 2024Article
- Review
- Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells.Frontiers in neuroscience · 2019Article
- High Time for Hair Cells: An Introduction to the Symposium on Sensory Hair Cells.Integrative and comparative biology · 2018Article
- Single-Cell Transcriptome Analysis of Developing and Regenerating Spiral Ganglion Neurons.Current pharmacology reports · 2016Article
- Where hearing starts: the development of the mammalian cochlea.Journal of anatomy · 2016Review
- Insm1 promotes neurogenic proliferation in delaminated otic progenitors.Mechanisms of development · 2015Article
- Inner ear development: building a spiral ganglion and an organ of Corti out of unspecified ectoderm.Cell and tissue research · 2015Review
- Sensory hair cell regeneration in the zebrafish lateral line.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Gene-expression analysis of hair cell regeneration in the zebrafish lateral line.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear.Developmental biology · 2013Article
- Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells.Seminars in cell & developmental biology · 2013Review
- Beyond generalized hair cells: molecular cues for hair cell types.Hearing research · 2013Review
- Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Evolution and development of the tetrapod auditory system: an organ of Corti-centric perspective.Evolution & development · 2013Review
- The use of neurotrophin therapy in the inner ear to augment cochlear implantation outcomes.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
- The myc road to hearing restoration.Cells · 2012Article
- Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Cell and tissue research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
This review summarizes recent progress in our understanding of the molecular basis of cochlear duct growth, specification of the organ of Corti, and differentiation of the different types of hair cells. Studies of multiple mutations suggest that developing hair cells are involved in stretching the organ of Corti through convergent extension movements. However, Atoh1 null mutants have only undifferentiated and dying organ of Corti precursors but show a near normal extension of the cochlear duct, implying that organ of Corti precursor cells can equally drive this process. Some factors influence cochlear duct growth by regulating the cell cycle and proliferation. Shortened cell cycle and premature cell cycle exit can lead to a shorter organ of Corti with multiple rows of hair cells (e.g., Foxg1 null mice). Other genes affect the initial formation of a cochlear duct with or without affecting the organ of Corti. Such observations are consistent with evolutionary data that suggest some developmental uncoupling of cochlear duct from organ of Corti formation. Positioning the organ of Corti requires multiple genes expressed in the organ of Corti and the flanking region. Several candidate factors have emerged but how they cooperate to specify the organ of Corti and the topology of hair cells remains unclear. Atoh1 is required for differentiation of all hair cells, but regulation of inner versus outer hair cell differentiation is still unidentified. In summary, the emerging molecular complexity of organ of Corti development demands further study before a rational approach towards regeneration of unique types of hair cells in specific positions is possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.