ArticleExperimental and molecular pathology2011
The immunoproteasome in steatohepatitis: its role in Mallory-Denk body formation.
Article in Experimental and molecular pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Immunoproteasome acted as immunotherapy 'coffee companion' in advanced carcinoma therapy.Frontiers in immunology · 2024Review
- Functional Characterization of Organoids Derived From Irreversibly Damaged Liver of Patients With NASH.Hepatology (Baltimore, Md.) · 2021Article
- The Role of FAT10 in Alcoholic Hepatitis Pathogenesis.Biomedicines · 2020Review
- Extended lifespan and reduced adiposity in mice lacking the FAT10 gene.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities.Age (Dordrecht, Netherlands) · 2014Article
- LMP2, a novel immunohistochemical marker to distinguish renal oncocytoma from the eosinophilic variant of chromophobe renal cell carcinoma.Experimental and molecular pathology · 2013Article
- Emerging roles of immunoproteasomes beyond MHC class I antigen processing.Cellular and molecular life sciences : CMLS · 2012Review
- The role of innate immunity in the pathogenesis of preneoplasia in drug-induced chronic hepatitis based on a mouse model.Experimental and molecular pathology · 2011Review
- Alcoholic liver disease: a synopsis of the Charles Lieber's Memorial Symposia 2009-2012.Alcohol and alcoholism (Oxford, Oxfordshire)Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Recently it has been shown that the expression of the immunoproteasome increased in proportion to the degree of chronic inflammation in both the liver cell cytoplasm and nuclei in liver biopsies from patients who had chronic active hepatitis or cirrhosis. In the present study, biopsies from patients with steatohepatitis, with or without Mallory-Denk body (MDB) formation, were studied by immunofluorescent staining. Normal liver showed colocalization of FAT10, LMP2, LMP7, and MECL-1 at the mitochondria. Only LMP2 and LMP7 were found in the cell nuclei. Liver biopsies from patients with steatohepatitis and MDB formation, and a case of hepatocellular carcinoma forming MDBs in the tumor cells, showed colocalization of FAT10 and ubiquitin with LMP2, LMP7 and MECL-1 within the MDB. This indicates involvement of the immunoproteasome in MDB formation in steatohepatitis cases and in a case of HCC forming MDBs. Prior studies have shown that the immunoproteasome was involved in drug-induced MDB formation using the same immunofluorescent colocalization approach as was used on these human liver biopsies. The increase in the immunoproteasome subunit proteins was made at the expense of the 26S proteasome. This indicates that the shift from the 26S to the immunoproteasome had occurred in the MDB positive hepatocytes.
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