ReviewPlacenta2011
Review: Genetic manipulation of the rodent placenta.
Review in Placenta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Mouse In Vivo Placental Targeted CRISPR Manipulation.Journal of visualized experiments : JoVE · 2023Article
- Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species.Animals : an open access journal from MDPI · 2023Article
- Review
- How trophoblasts fuse: an in-depth look into placental syncytiotrophoblast formation.Cellular and molecular life sciences : CMLS · 2022Review
- Novel Technologies for Target Delivery of Therapeutics to the Placenta during Pregnancy: A Review.Genes · 2021Review
- The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth†.Biology of reproduction · 2019Review
- CCDC134 serves a crucial role in embryonic development.International journal of molecular medicine · 2018Article
- Transposase-mediated gene modulation in the placenta.Placenta · 2017Review
- Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.Cell death & disease · 2017Article
- Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.American journal of obstetrics and gynecology · 2016Article
- Adrenomedullin promotes rat trophoblast stem cell differentiation.Biology of reproduction · 2014Article
- In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy.PloS one · 2014Article
- Ex vivo perfusion of mid-to-late-gestation mouse placenta for maternal-fetal interaction studies during pregnancy.Nature protocols · 2013Article
- Gestational protein restriction affects trophoblast differentiation.Frontiers in bioscience (Elite edition) · 2013Article
- Transient, inducible, placenta-specific gene expression in mice.Endocrinology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The principal role of the placenta is the maintenance of pregnancy and promotion of fetal growth and viability. The use of transgenic rodents has greatly enhanced our understanding of placental development and function. However, embryonic lethality is often a confounding variable in determining whether a genetic modification adversely affected placental development. In these cases, it is beneficial to specifically manipulate the placental genome. The purpose of this review is to summarize available methodologies for specific genetic modification of the rodent placenta. By restricting genetic alterations to the trophoblast lineage, it is possible to gain a deeper understanding of placental development that perhaps will lead to gene-targeted therapies to rescue irregular placentation in transgenic animals or in women at high-risk for placenta-associated pregnancy complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.