ArticleThe Journal of pediatrics2011
Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infants.
Article in The Journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Carbohydrate supplementation of human milk to promote growth in preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Carbohydrate supplementation of human milk to promote growth in preterm infants.The Cochrane database of systematic reviews · 2018Pooled it
- Infants Fed Breastmilk or 2'-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids.Nutrients · 2023Trial
- Human milk oligosaccharides and their association with late-onset neonatal sepsis in Peruvian very-low-birth-weight infants.The American journal of clinical nutrition · 2020Trial
- Human milk oligosaccharides in premature infants: absorption, excretion, and influence on the intestinal microbiota.Pediatric research · 2015Trial
- A case report of soluble A antigen confounding the blood type in a haplo-identical hematopoietic stem cell transplant patient with graft-versus-host disease.Transfusion · 2026Article
- Infant Botulism and Carbohydrate Blood Group Antigens: Preliminary Results from a Discordant Twin Study.Journal of pediatrics. Clinical practice · 2025Article
- Guardian of the gut: butyrate-regulated FUT2 protects against experimental NEC.Pediatric research · 2025Article
- Role of Human Milk Microbiota in Infant Neurodevelopment: Mechanisms and Clinical Implications.Children (Basel, Switzerland) · 2024Review
- Human milk oligosaccharides and the association with microbiota in colostrum: a pilot study.Archives of microbiology · 2024Article
- Human milk oligosaccharides in milk of mothers with term and preterm delivery at different lactation stage.Carbohydrate polymers · 2023Article
- Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites.International journal of molecular sciences · 2023Review
- Gut Microbiome Composition and Metabolic Capacity Differ byNutrients · 2023Article
- Fucosylated TLR4 mediates communication between mutualist fucotrophic microbiota and mammalian gut mucosa.Frontiers in medicine · 2023Article
- Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes.Nature communications · 2022Article
- Neonatal infections: Insights from a multicenter longitudinal research collaborative.Seminars in perinatology · 2022Article
- Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration.Nature communications · 2022Article
- FUT2 gene as a genetic susceptible marker of infectious diseases: A Review.International journal of molecular epidemiology and genetics · 2022Review
- Review
- Maternal H-antigen secretor status is an early biomarker for potential preterm delivery.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo investigate secretor gene fucosyltransferase 2 (FUT2) polymorphism and secretor phenotype in relation to outcomes of prematurity. STUDY
designStudy infants were ≤32 weeks gestational age. Secretor genotype was determined from salivary DNA. Secretor phenotype was measured with H antigen, the carbohydrate produced by secretor gene enzymes, in saliva samples collected on day 9 ± 5. The optimal predictive cutoff point in salivary H values was identified with Classification and Regression Tree analysis. Study outcomes were death, necrotizing enterocolitis (NEC, Bell's stage II/III), and confirmed sepsis.
resultsThere were 410 study infants, 26 deaths, 30 cases of NEC, and 96 cases of sepsis. Analyzed by genotype, 13% of 95 infants who were non-secretors, 5% of 203 infants who were heterozygotes, and 2% of 96 infants who were secretor dominant died (P = .01). Analyzed by phenotype, 15% of 135 infants with low secretor phenotype died, compared with 2% of 248 infants with high secretor phenotype (predictive value = 76%, P < .001). Low secretor phenotype was associated (P < .05) with NEC, and non-secretor genotype was associated (P = .05) with gram negative sepsis. Secretor status remained significant after controlling for multiple clinical factors.
conclusionsSecretor genotype and phenotype may provide strong predictive biomarkers of adverse outcomes in premature infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.