Evidence map›Paper›PMID 21256475›Full record

Trial reportBehaviour research and therapy2011

Behavioral interventions may prolong remission in patients with inflammatory bowel disease.

Laurie Keefer, Jennifer L Kiebles, Zoran Martinovich, Elyse Cohen, Alyssa Van Denburg, Terrence A Barrett

Abstract readClinical Trial
In one paragraph

Trial report in Behaviour research and therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Psychological interventions for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. A Systematic Review of Self-Management Interventions for Inflammatory Bowel Disease.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2016
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Inflammatory Bowel Disease Patient Experiences with Psychotherapy in the Community.Journal of clinical psychology in medical settings · 2019
    Article
  12. Article
  13. Review
  14. Psychological status in Iranian patients with ulcerative colitis and its relation to disease activity and quality of life.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015
    Article
  15. Article
  16. Chronic cough: a gastroenterology perspective.Current opinion in otolaryngology & head and neck surgery · 2013
    Review
  17. Refractory inflammatory bowel disease-could it be an irritable bowel?Nature reviews. Gastroenterology & hepatology · 2013
    Review
  18. Personality dimensions and type D personality in female patients with ulcerative colitis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012
    Article
  19. Psychological issues in inflammatory bowel disease: an overview.Gastroenterology research and practice · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Laurie KeeferDivision of Gastroenterology, Northwestern University Feinberg School of Medicine, Center for Psychosocial Research, 676N. St. Clair, Suite 1400, Chicago, IL 60611, USA. laurie.keefer@northwestern.edu
Jennifer L Kiebles
Zoran Martinovich
Elyse Cohen
Alyssa Van Denburg
Terrence A Barrett
Northwestern University · US

Funding

THE ROLE OF GUT-DIRECTED HYPNOTHERAPY IN RELAPSE PREVENTION FOR ULCERATIVE COLITIR21AT003204 · NCCIH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KEEFER, LAURIE A · 2008 to 2010
$625k
NCCIH NIH HHS R21 AT003204NCCIH NIH HHS R21AT003204
6 · The paper itself

Abstract

unlabelledInflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse. PURPOSE: We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following behavioral intervention when compared to the natural history of flare incidence prior to program participation.

resultsResults from a 2-level regression model indicated that those participants in the treatment group were 57% less likely to flare in the following 12 months (compared to 18% in the control group). The decline in "flare odds" was about 2 times greater in treatment versus controls (OR=0.52, t(34)=2.07, p<0.05). Office visits, ER visits, and disease severity (all p<0.05) were identified as moderators of flare risk.

conclusionsWe have demonstrated 1) a statistical model estimating the likelihood of flare rates in the 12 months following a behavioral intervention for IBD (compared to a control condition), and 2) that the introduction of a behavioral intervention can alter the natural course of a chronic, relapsing and remitting gastrointestinal condition such as IBD.

Indexed as

Cognitive Behavioral TherapyHypnosisAdolescentAdultAgedCross-Over StudiesFemaleHumansInflammatory Bowel DiseasesMaleMiddle AgedRegression AnalysisSecondary PreventionSelf CareSeverity of Illness IndexTreatment Outcome

Identifiers

PMID21256475
PMCPMC3042537
OpenAlexW2141578253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.