ArticleNeurotoxicology and teratology
Unpacking the association: Individual differences in the relation of prenatal exposure to cigarettes and disruptive behavior phenotypes.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Heterogeneity in Callous-Unemotional Traits: Early Temperamental and Environmental Risk Factors in a High-Risk Sample.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Prenatal and Postnatal Exposure to Tobacco and Cannabis and Child Aggression at Early School Age: Role of Early Maternal Sensitivity.Child psychiatry and human development · 2026Article
- Disruptive behavior in preschoolers: associations with attention deficit hyperactivity disorder and parental psychopathology.BMC psychiatry · 2026Article
- Extending the Environmental influences on Child Health Outcomes (ECHO) Cohort through 2030: Rationale and study protocol.PloS one · 2024Observational
- Topic modeling for systematic review of visual analytics in incomplete longitudinal behavioral trial data.Smart health (Amsterdam, Netherlands) · 2020Article
- Principles for Guiding the Selection of Early Childhood Neurodevelopmental Risk and Resilience Measures: HEALthy Brain and Child Development Study as an Exemplar.Adversity and resilience science · 2020Article
- Responsive Parenting Buffers the Impact of Maternal PTSD on Young Children.Parenting, science and practice · 2020Article
- Does early maternal responsiveness buffer prenatal tobacco exposure effects on young children's behavioral disinhibition?Development and psychopathology · 2019Article
- Measurement framework for the Environmental influences on Child Health Outcomes research program.Current opinion in pediatrics · 2018Review
- Intrauterine exposure to tobacco and executive functioning in high school.Drug and alcohol dependence · 2017Article
- Cohort Profile: The Saguenay Youth Study (SYS).International journal of epidemiology · 2017Article
- Prenatal tobacco exposure and self-regulation in early childhood: Implications for developmental psychopathology.Development and psychopathology · 2015Article
- Saguenay Youth Study: a multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health.Developmental cognitive neuroscience · 2015Article
- Advancing a multidimensional, developmental spectrum approach to preschool disruptive behavior.Journal of the American Academy of Child and Adolescent Psychiatry · 2014Article
- Changes in smoking patterns during pregnancy.Substance use & misuse · 2013Article
- Parenting practices in pregnancy smokers compared to non smokers.Journal of clinical medicine research · 2013Article
- Smoking during pregnancy and psychiatric disorders in preschoolers.European child & adolescent psychiatry · 2012Article
- Detecting graded exposure effects: a report on an East Boston pregnancy cohort.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Article
- Putting theory to the test: modeling a multidimensional, developmentally-based approach to preschool disruptive behavior.Journal of the American Academy of Child and Adolescent Psychiatry · 2012Article
- Connecting ncRNA Cigarette Smoking Studies with Tobacco Use Behaviors and Health Outcomes.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Prenatal exposure to cigarettes has been robustly associated with disruptive behavior in diverse samples and across developmental periods. In this paper we aim to elucidate exposure related behavioral phenotypes and developmental pathways by testing: (a) differential associations of exposure and four disruptive behavior dimensional phenotypes: Aggression, Noncompliance, Temper Loss and Low Concern for Others; and (b) moderation of these pathways including sex differences and moderation by parental responsive engagement. Participants were 211 teens and their parents from the East Boston Family Study (EBFS), an adolescent follow-up of a pregnancy cohort over-sampled for exposure. A best estimate serum cotinine corrected score was used to characterize exposure. In multivariate models controlling for parental antisocial behavior, family adversity and secondhand exposure, exposure uniquely predicted Aggression and Noncompliance. Paternal responsiveness moderated exposure effects on disruptive behavior. There were no sex differences in these patterns. Phenotypic findings suggest the possibility of specific neural mechanisms. In conjunction with prior research, protective effects of parental responsiveness occurring as late as adolescence point to the potential benefit of parenting-based prevention efforts to reduce risk to exposed offspring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.