Evidence map›Paper›PMID 21256425›Full record

ArticleNeurotoxicology and teratology

The effects of prenatal cocaine exposure and gender on inhibitory control and attention.

Dennis P Carmody, David S Bennett, Michael Lewis

Abstract read
In one paragraph

Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
8.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Self-Recognition and Emotional Knowledge.The European journal of developmental psychology · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Effects of Fetal Substance Exposure on Offspring Substance Use.Pediatric clinics of North America · 2019
    Review
  13. Review
  14. Cocaine-induced neurodevelopmental deficits and underlying mechanisms.Birth defects research. Part C, Embryo today : reviews · 2016
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dennis P CarmodyInstitute for the Study of Child Development, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.
David S Bennett
Michael Lewis
Drexel University · US

Funding

DEVELOPMENTAL EFFECTS OF PRENATAL COCAINE EXPOSURER01DA007109 · NIDA · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BENNETT, DAVID S, CARMODY, DENNIS P · 1992 to 2012
$11.3M
NIDA NIH HHS R01 DA007109NIDA NIH HHS R01-DA07109
6 · The paper itself

Abstract

Children exposed prenatally to cocaine show deficits in emotion regulation and inhibitory control. While controlling for the measures of medical complication in the perinatal period, environmental risk, and prenatal polydrug exposure (alcohol, tobacco, and marijuana), we examined the effects of prenatal cocaine exposure and gender on attention and inhibitory control in 203 children at ages 6, 9, and 11. Cocaine exposure affected the performance of males, but not females. Heavily exposed males showed deficits in the attention and the inhibition tasks. In addition, a significantly greater proportion of heavily exposed males (21%) than unexposed males (7%) or heavily exposed females (7%) failed to complete the task (p<0.01). Even without those poorest performing subjects, the overall accuracy for heavily exposed males (81%) was significantly reduced (p<0.05) compared to lightly exposed males (87%) and unexposed males (89%). The findings highlight the importance of considering gender specificity in cocaine exposure effects. Processes by which cocaine effects may be specific to males are discussed.

Indexed as

AttentionChildChild BehaviorCocaineData Interpretation, StatisticalFemaleHumansLongitudinal StudiesMalePregnancyPrenatal Exposure Delayed EffectsSex FactorsSocial ClassSubstance-Related DisordersCocaine

Identifiers

PMID21256425
PMCPMC3052746
OpenAlexW2146388545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.