ArticleNeurotoxicology and teratology
Adolescents with and without gestational cocaine exposure: Longitudinal analysis of inhibitory control, memory and receptive language.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations of Prescribed ADHD Medication in Pregnancy with Pregnancy-Related and Offspring Outcomes: A Systematic Review.CNS drugs · 2020Pooled it
- Pooled it
- Trial
- Early emotional caregiving environment and associations with memory performance and hippocampal volume in adolescents with prenatal drug exposure.Frontiers in behavioral neuroscience · 2023Article
- How the war on drugs impacts social determinants of health beyond the criminal legal system.Annals of medicine · 2022Review
- Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring.Psychopharmacology · 2019Article
- Increased cocaine and amphetamine-regulated transcript cord blood levels in the newborns exposed to crack cocaine in utero.Psychopharmacology · 2018Article
- Prenatal Cocaine Exposure Impacts Language and Reading Into Late Adolescence: Behavioral and ERP Evidence.Developmental neuropsychology · 2017Article
- Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling.PloS one · 2016Article
- Effect of socioeconomic status disparity on child language and neural outcome: how early is early?Pediatric research · 2016Review
- Complicating the dominant morality discourse: mothers and fathers' constructions of substance use during pregnancy and early parenthood.International journal for equity in health · 2015Article
- What matters most: quantifying an epidemiology of consequence.Annals of epidemiology · 2015Review
- Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Prenatal Substance Use: Exploring Assumptions of Maternal Unfitness.Substance abuse : research and treatment · 2015Article
- Neurobehavioral and Developmental Traiectories Associated with Level of Prenatal Cocaine Exposure.Journal of neurology and psychology · 2014Article
- Relations among prospective memory, cognitive abilities, and brain structure in adolescents who vary in prenatal drug exposure.Journal of experimental child psychology · 2014Article
- Prenatal cocaine effects on brain structure in early infancy.NeuroImage · 2014Article
- Human infancy…and the rest of the lifespan.Annual review of psychology · 2014Review
- Prenatal drug exposure moderates the association between stress reactivity and cognitive function in adolescence.Developmental neuroscience · 2014Article
- Language outcomes at 12 years for children exposed prenatally to cocaine.Journal of speech, language, and hearing research : JSLHR · 2013Article
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Authors and funding
8 authors.
Funding
Abstract
Preclinical studies of gestational cocaine exposure (GCE) show evidence of changes in brain function at the anatomical, physiological, and behavioral levels, to include effects on developing dopaminergic systems. In contrast, human studies have produced less consistent results, with most showing small effects or no effects on developmental outcomes. Important changes in brain structure and function occur through adolescence, therefore it is possible that prenatal cocaine exposure has latent effects on neurocognitive (NC) outcome that do not manifest until adolescence or young adulthood. We examined NC function using a set of 5 tasks designed to tap 4 different systems: inhibitory control, working memory, receptive language, and incidental memory. For each NC task, data were collected longitudinally at ages 12, 14.5 and 17 years and examined using generalized estimating equations. One hundred and nine children completed at least two of the three evaluations. Covariates included in the final model were assessment number, gender, participant age at first assessment, caregiver depression, and two composites from the Home Observation for Measurement of the Environment (HOME), Environmental Stimulation and Parental Nurturance. We found no cocaine effects on inhibitory control, working memory, or receptive language (p=0.18). GCE effects were observed on incidental face memory task (p=0.055), and GCE by assessment number interaction effects were seen on the incidental word memory task (p=0.031). Participant performance on inhibitory control, working memory, and receptive language tasks improved over time. HOME Environmental Stimulation composite was associated with better receptive language functioning. With a larger sample size smaller differences between groups may have been detected. This report shows no evidence of latent effects of GCE on inhibitory control, working memory, or receptive language. GCE effects were observed on the incidental face memory task, and GCE by assessment number interaction effects was seen on the incidental word memory task.
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