ReviewReproductive toxicology (Elmsford, N.Y.)2011
Prenatal environmental exposures, epigenetics, and disease.
Review in Reproductive toxicology (Elmsford, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 284 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
284 citing papers in PubMed, 9 syntheses or guidelines pooled it, 632 citations in OpenAlex.
- Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood.Journal of child psychology and psychiatry, and allied disciplines · 2026Pooled it
- Familial and genetic overlap between Sjögren's disease and other autoimmune diseases.Frontiers in immunology · 2026Pooled it
- The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis.Clinical epigenetics · 2023Pooled it
- 'Omics in environmental epidemiological studies of chemical exposures: A systematic evidence map.Environment international · 2022Pooled it
- Systemic review of genetic and epigenetic factors underlying differential toxicity to environmental lead (Pb) exposure.Environmental science and pollution research international · 2022Pooled it
- DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium.Environmental research · 2022Pooled it
- Role of psychotherapy on antenatal depression, anxiety, and maternal quality of life: A meta-analysis.Medicine · 2020Pooled it
- A Systematic Review and Meta-Analysis Investigating the Relationship between Exposures to Chemical and Non-Chemical Stressors during Prenatal Development and Childhood Externalizing Behaviors.International journal of environmental research and public health · 2020Pooled it
- Exploring the endocrine activity of air pollutants associated with unconventional oil and gas extraction.Environmental health : a global access science source · 2018Pooled it
- Article
- Population epigenetics: deciphering DNA methylation diversity and its implications for health, disease, and evolution.Molecular biology and evolution · 2026Review
- The environmental exposome in heart failure risk and progression.Nature reviews. Cardiology · 2026Review
- ToxiTaRGET: a multi-omics database for toxicant-responsive molecular targets.Nature communications · 2026Article
- Sex-Specific sRNA Signatures in Rat Liver Reveal Divergent Alterations Following Perinatal Exposure to Glyphosate and Its Mixture with 2,4-D and Dicamba.International journal of molecular sciences · 2026Article
- Environmental Exposure-Induced Epigenetic Modifications and Adverse Pregnancy Outcomes: A Systematic Review.Cureus · 2026Review
- Benzo[a]pyrene exposure affect the formation of dental hard tissue via the regulation of glycerophospholipid metabolism.BMC oral health · 2026Article
- Progeny effects of rotenone exposure depend on parental toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Impact of a prenatal exposure mixture of metals on DNA methylation-derived cell-type composition in cord blood.Environmental epigenetics · 2026Article
- DNA methylation as a biomarker of prenatal exposures: current challenges and opportunities.Environmental epigenetics · 2026Review
- Gestational exposure to the artificial sweetener erythritol reprograms ovarian function through AMH suppression and oxidative stress-mediated disruption of autophagy and PI3K signaling.Frontiers in endocrinology · 2026Article
224 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
This review summarizes recent evidence that prenatal exposure to diverse environmental chemicals dysregulates the fetal epigenome, with potential consequences for subsequent developmental disorders and disease manifesting in childhood, over the lifecourse, or even transgenerationally. The primordial germ cells, embryo, and fetus are highly susceptible to epigenetic dysregulation by environmental chemicals, which can thereby exert multiple adverse effects. The data reviewed here on environmental contaminants have potential implications for risk assessment although more data are needed on individual susceptibility to epigenetic alterations and their persistence before this information can be used in formal risk assessments. The findings discussed indicate that identification of environmental chemicals that dysregulate the prenatal epigenome should be a priority in health research and disease prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.