ReviewPharmacology & therapeutics2011
MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease.
Review in Pharmacology & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis.International journal of molecular sciences · 2016Pooled it
- Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication.International journal of molecular sciences · 2024Review
- Current progression in application of extracellular vesicles in central nervous system diseases.European journal of medical research · 2024Review
- Children with Autism Spectrum Disorder and Abnormalities of Clinical EEG: A Qualitative Review.Journal of clinical medicine · 2024Review
- miR-155: An Important Role in Inflammation Response.Journal of immunology research · 2022Review
- Emerging Role of microRNAs in Stroke Protection Elicited by Remote Postconditioning.Frontiers in neurology · 2021Review
- MicroRNA profiling of the pig periaqueductal grey (PAG) region reveals candidates potentially related to sex-dependent differences.Biology of sex differences · 2020Article
- NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity.The EMBO journal · 2018Article
- Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity.Non-coding RNA · 2018Review
- miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Involvement of microRNA-133 and -29 in cardiac disturbances in diabetic ovariectomized rats.Iranian journal of basic medical sciences · 2016Article
- Down-Regulation of MicroRNA-133b Suppresses Apoptosis of Lens Epithelial Cell by Up-Regulating BCL2L2 in Age-Related Cataracts.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- MicroRNAs and drug-induced kidney injury.Pharmacology & therapeutics · 2016Review
- MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis.BBA clinical · 2015Article
- MicroRNA and epilepsy: profiling, functions and potential clinical applications.Current opinion in neurology · 2014Review
- Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications.Dialogues in clinical neuroscience · 2014Review
- Synaptic adaptations by alcohol and drugs of abuse: changes in microRNA expression and mRNA regulation.Frontiers in molecular neuroscience · 2014Review
- MicroRNA-132 may play a role in coexistence of depression and cardiovascular disease: a hypothesis.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- MicroRNAs as effectors of brain function.Stroke · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs are members of the non-protein-coding family of RNAs. They serve as regulators of gene expression by modulating the translation and/or stability of messenger RNA targets. The discovery of microRNAs has revolutionized the field of cell biology, and has permanently altered the prevailing view of a linear relationship between gene and protein expression. The increased complexity of gene regulation is both exciting and daunting, as emerging evidence supports a pervasive role for microRNAs in virtually every cellular process. This review briefly describes microRNA processing and formation of RNA-induced silencing complexes, with a focus on the role of RNA binding proteins in this process. We also discuss mechanisms for microRNA-mediated regulation of translation, particularly in dendritic spine formation and function, and the role of microRNAs in synaptic plasticity. We then discuss the evidence for altered microRNA function in cognitive brain disorders, and the effect of gene mutations revealed by single nucleotide polymorphism analysis on altered microRNA function and human disease. Further, we present evidence that altered microRNA expression in circulating fluids such as plasma/serum can correlate with, and serve as, novel diagnostic biomarkers of human disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.