ArticlePsychoneuroendocrinology2011
Behavioral effects of peripheral corticotropin-releasing factor during maternal separation may be mediated by proinflammatory activity.
Article in Psychoneuroendocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Examination of the role of adrenergic receptor stimulation in the sensitization of neuroinflammatory-based depressive-like behavior in isolated Guinea pig pups.Stress (Amsterdam, Netherlands) · 2023Article
- Central oxytocin alters cortisol and behavioral responses of guinea pig pups during isolation in a novel environment.Physiology & behavior · 2019Article
- Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies.Frontiers in cellular neuroscience · 2019Article
- Early Attachment Disruption, Inflammation, and Vulnerability for Depression in Rodent and Primate Models.Frontiers in behavioral neuroscience · 2018Article
- Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress.Scientific reports · 2017Article
- Observational
- Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines.Psychoneuroendocrinology · 2016Article
- Maternal inhibition of infant behavioral response following isolation in novel surroundings and inflammatory challenge.Developmental psychobiology · 2013Article
- Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.Behavioral neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
When guinea pig pups are separated from their mothers in a novel environment, an initial period of active behavior (vocalizing, locomotor activity) wanes after an hour or so and is replaced by a second, passive stage characterized by a crouched stance, closed eyes, and extensive piloerection. If pups are given a peripheral injection of 7-14μg of corticotropin-releasing factor (CRF) prior to testing, the passive behaviors occur immediately upon separation. We found that intracerebroventricular infusion of 1-10μg of CRF did not increase passive behavior relative to vehicle infusion, but that peripheral injection of the anti-inflammatory cytokine, interleukin-10, attenuated the passive behavior induced by peripheral CRF injection. These results together with previous findings suggest that peripheral CRF administration affects behavior of separated guinea pig pups through a mechanism that involves peripheral proinflammatory activity. The possible role of endogenous peripheral CRF in the behavioral response of untreated pups during maternal separation is considered.
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Registered trials
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