Evidence map›Paper›PMID 21255834›Full record

ArticleLeukemia research2011

Correlation among nuclear localization of NuMA-RARα, deregulation of gene expression and leukemic phenotype of hCG-NuMA-RARα transgenic mice.

Mahadeo A Sukhai, Mariam Thomas, Soheila A Hamadanizadeh, Yali Xuan, Richard A Wells, Suzanne Kamel-Reid

Abstract read
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In one paragraph

Article in Leukemia research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mahadeo A SukhaiDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Mariam Thomas
Soheila A Hamadanizadeh
Yali Xuan
Richard A Wells
Suzanne Kamel-Reid
University Health Network · CAUniversity of Toronto · CASunnybrook Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute promyelocytic leukemia (APL) is a model system of aberrant transcription in cancer. We sought to elucidate the mechanism of action of the variant fusion NuMA-RARα in APL, using the hCG-NuMA-RARα transgenic model. We report that subcellular localization of NuMA-RARα in transgenic mice is dependent upon its protein expression and transgene dosage. Subcellular localization of the fusion is inversely correlated with extent of gene deregulation at the mRNA level for Cebpα, Cebpɛ and Pu.1. Finally, we report that phenotype onset is correlated with NuMA-RARα copy number; mice with higher copy number developing disease later than those with lower copy number.

Indexed as

AnimalsCell NucleusChorionic GonadotropinCytoplasmDisease Models, AnimalGene DosageGene Expression Regulation, LeukemicHumansLeukemiaMiceMice, TransgenicOncogene Proteins, FusionPhenotypeProtein TransportTransgenesU937 CellsChorionic GonadotropinNuMa-RARalpha protein, humanOncogene Proteins, Fusion

Identifiers

PMID21255834
OpenAlexW2041743288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.