ReviewPulmonary pharmacology & therapeutics2011
Multiscale mathematical models of airway constriction and disease.
Review in Pulmonary pharmacology & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Comparison of Inspiratory Effort, Workload and Cycling Synchronization Between Non-Invasive Proportional-Assist Ventilation and Pressure-Support Ventilation Using Different Models of Respiratory Mechanics.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- A review of inflammatory mechanism in airway diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics.PloS one · 2017Article
- Emergence of airway smooth muscle mechanical behavior through dynamic reorganization of contractile units and force transmission pathways.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM).Interface focus · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Loss of lung function in airway disease frequently involves many complex phenomena and interconnected underlying causes. In many conditions, such as asthmatic airway hyper-responsiveness, hypothesised underlying causes span multiple spatial scales. In cases like this, it is insufficient to take a reductionist approach, wherein each subsystem (at a given spatial scale) is considered in isolation and then the whole is taken to be merely the sum of the parts; this is because there can be significant and important interactions and synergies between spatial scales. Experimentally this can manifest as, for example, significant differences between behaviour in isolated tissue and that seen in vivo, while from a modelling perspective, it necessitates multiscale modelling approaches. Because it is precisely in these complex environs that models have the greatest potential to improve understanding of underlying behaviours, these multiscale models are of particular importance. This paper reviews several examples of multiscale models from the most important models in the literature, with a particular emphasis on those concerned with airway hyper-responsiveness and airway constriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.