ArticleNeuroscience letters2011
Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation.
Article in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Dysregulation of protein SUMOylation networks in Huntington's disease R6/2 mouse striatum.Brain : a journal of neurology · 2025Article
- Review
- SUMOylation and Major Depressive Disorder.International journal of molecular sciences · 2022Review
- Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα.International journal of molecular sciences · 2021Article
- SUMOylation of synaptic and synapse-associated proteins: An update.Journal of neurochemistry · 2021Review
- Metabotropic glutamate receptor trafficking.Molecular and cellular neurosciences · 2018Review
- Commentary: Analysis of SUMO1-conjugation at synapses.Frontiers in cellular neuroscience · 2017Article
- Sumoylation in Synaptic Function and Dysfunction.Frontiers in synaptic neuroscience · 2016Review
- Receptor trafficking and the regulation of synaptic plasticity by SUMO.Neuromolecular medicine · 2013Review
- Loss of SUMOylation on ATF3 inhibits proliferation of prostate cancer cells by modulating CCND1/2 activity.International journal of molecular sciences · 2013Article
- Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7.British journal of pharmacology · 2012Article
- Protein SUMOylation in spine structure and function.Current opinion in neurobiology · 2012Review
- Regulation of Neuronal Protein Trafficking and Translocation by SUMOylation.Biomolecules · 2012Article
- Structure of metabotropic glutamate receptor C-terminal domains in contact with interacting proteins.Frontiers in molecular neuroscience · 2012Article
- Activity-dependent SUMOylation of the brain-specific scaffolding protein GISP.Biochemical and biophysical research communications · 2011Article
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Group III metabotropic glutamate receptors (mGluRs) undergo post-translational modification by SUMO in in vitro assays but the SUMOylation of full-length mGluRs in mammalian cells has not been reported. Here we investigated SUMOylation of mGluR7 in HEK293 cells and primary cortical neurons in an attempt to confirm SUMOylation and define physiological effects on mGluR7 function. Using a recombinant bacterial expression assay we validated in vitro SUMOylation of the C-terminal domain of mGluR7 by both SUMO-1 and SUMO-2 and show that a single lysine residue (K889) in mGluR7 is required for SUMOylation. However, using a range of approaches, we were unable to detect SUMOylation of full-length mGluR7 in either heterologous cells or neurons. Further, we observed no differences in receptor stability or surface expression between wild-type and a non-SUMOylatable point mutant mGluR7. Thus, our results question whether mGluR7, and by implication other group III mGluRs, are physiologically relevant neuronal SUMO substrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.