ArticleBMC systems biology2011
When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases.
Article in BMC systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Viral Induced Oxidative and Inflammatory Response in Alzheimer's Disease Pathogenesis with Identification of Potential Drug Candidates: A Systematic Review using Systems Biology Approach.Current neuropharmacology · 2019Pooled it
- A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens.PloS one · 2012Pooled it
- Integrative Bioinformatic Approach for microRNA Interactome Networks in Human Papillomavirus-16 Infection.The Eurasian journal of medicine · 2025Article
- Deciphering Host-Virus Interactions and Advancing Therapeutics for Chronic Viral Infection.Viruses · 2025Review
- MALAT1 and HIST1H2BC as connecting diagnostic biomarkers in Ebola and its overlapping disease: An integrative approach.Bioinformation · 2025Article
- Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Network for network concept offers new insights into host- SARS-CoV-2 protein interactions and potential novel targets for developing antiviral drugs.Computers in biology and medicine · 2022Review
- Protein-protein interactions: Methods, databases, and applications in virus-host study.World journal of virology · 2021Review
- Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approaches.Briefings in bioinformatics · 2021Article
- Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Rationale and Criteria for a COVID-19 Model Framework.Viruses · 2021Article
- A scheme for inferring viral-host associations based on codon usage patterns identifies the most affected signaling pathways during COVID-19.Journal of biomedical informatics · 2021Article
- Protein-protein interactions of human viruses.Seminars in cell & developmental biology · 2020Review
- Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis.Frontiers in immunology · 2019Article
- Defining Pharmacological Targets by Analysis of Virus-Host Protein Interactions.Advances in protein chemistry and structural biology · 2018Review
- Article
- Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins.Microbiome · 2017Article
- TheFrontiers in aging neuroscience · 2017Article
- Network analysis reveals common host protein/s modulating pathogenesis of neurotropic viruses.Scientific reports · 2016Article
- DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions.PLoS neglected tropical diseases · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComprehensive understanding of molecular mechanisms underlying viral infection is a major challenge towards the discovery of new antiviral drugs and susceptibility factors of human diseases. New advances in the field are expected from systems-level modelling and integration of the incessant torrent of high-throughput "-omics" data.
resultsHere, we describe the Human Infectome protein interaction Network, a novel systems virology model of a virtual virus-infected human cell concerning 110 viruses. This in silico model was applied to comprehensively explore the molecular relationships between viruses and their associated diseases. This was done by merging virus-host and host-host physical protein-protein interactomes with the set of genes essential for viral replication and involved in human genetic diseases. This systems-level approach provides strong evidence that viral proteomes target a wide range of functional and inter-connected modules of proteins as well as highly central and bridging proteins within the human interactome. The high centrality of targeted proteins was correlated to their essentiality for viruses' lifecycle, using functional genomic RNAi data. A stealth-attack of viruses on proteins bridging cellular functions was demonstrated by simulation of cellular network perturbations, a property that could be essential in the molecular aetiology of some human diseases. Networking the Human Infectome and Diseasome unravels the connectivity of viruses to a wide range of diseases and profiled molecular basis of Hepatitis C Virus-induced diseases as well as 38 new candidate genetic predisposition factors involved in type 1 diabetes mellitus.
conclusionsThe Human Infectome and Diseasome Networks described here provide a unique gateway towards the comprehensive modelling and analysis of the systems level properties associated to viral infection as well as candidate genes potentially involved in the molecular aetiology of human diseases.
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