ArticleMicrobial biotechnology2010
Hydrophobic substances induce water stress in microbial cells.
Article in Microbial biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 137 citations in OpenAlex.
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- Microbiological and toxicity analyses of the synthetic polymer polyhexamethylene guanidine hydrochloride against endodontic microorganisms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Burning question: Rethinking organohalide degradation strategy for bioremediation applications.Microbial biotechnology · 2024Review
- Enhanced chaotrope tolerance and (S)-2-hydroxypropiophenone production by recombinant Pseudomonas putida engineered with Pprl from Deinococcus radiodurans.Microbial biotechnology · 2024Article
- Modes-of-action of antifungal compounds: Stressors and (target-site-specific) toxins, toxicants, or toxin-stressors.Microbial biotechnology · 2023Review
- Scientific novelty beyond the experiment.Microbial biotechnology · 2023Article
- Significance of both alkB and P450 alkane-degrading systems in Tsukamurella tyrosinosolvens: proteomic evidence.Applied microbiology and biotechnology · 2022Article
- Water is a preservative of microbes.Microbial biotechnology · 2022Article
- Microorganisms populating the water-related indoor biome.Applied microbiology and biotechnology · 2020Review
- Protective Role of Bacterial Alkanesulfonate Monooxygenase under Oxidative Stress.Applied and environmental microbiology · 2020Article
- Viridistratins A-C, Antimicrobial and Cytotoxic Benzo[Biomolecules · 2020Article
- Evaluating cytotoxicity of methyl benzoateHeliyon · 2020Article
- Wooden owl that redefines Earth's biosphere may yet catapult a fungus into space.Environmental microbiology · 2019Article
- Selective extraction of lactoferrin from acidic whey using CTAB/n-heptanol reverse micellar system.Journal of food science and technology · 2019Article
- DNA Adsorption Studies of Poly(4,4'-Cychlohexylidene Bisphenol Oxalate)/Silica Nanocomposites.Materials (Basel, Switzerland) · 2019Article
- Synthesis, Characterization, and Application of Poly(4,4'-Cyclohexylidene Bisphenol Oxalate) for Solid-Phase Extraction of DNA.BioMed research international · 2019Article
- Bacillus megaterium adapts to acid stress condition through a network of genes: Insight from a genome-wide transcriptome analysis.Scientific reports · 2018Article
- Biosynthesis of the antimicrobial cyclic lipopeptides nunamycin and nunapeptin by Pseudomonas fluorescens strain In5 is regulated by the LuxR-type transcriptional regulator NunF.MicrobiologyOpen · 2017Article
- Metabolic and stress responses of Acinetobacter oleivorans DR1 during long-chain alkane degradation.Microbial biotechnology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Ubiquitous noxious hydrophobic substances, such as hydrocarbons, pesticides and diverse industrial chemicals, stress biological systems and thereby affect their ability to mediate biosphere functions like element and energy cycling vital to biosphere health. Such chemically diverse compounds may have distinct toxic activities for cellular systems; they may also share a common mechanism of stress induction mediated by their hydrophobicity. We hypothesized that the stressful effects of, and cellular adaptations to, hydrophobic stressors operate at the level of water : macromolecule interactions. Here, we present evidence that: (i) hydrocarbons reduce structural interactions within and between cellular macromolecules, (ii) organic compatible solutes - metabolites that protect against osmotic and chaotrope-induced stresses - ameliorate this effect, (iii) toxic hydrophobic substances induce a potent form of water stress in macromolecular and cellular systems, and (iv) the stress mechanism of, and cellular responses to, hydrophobic substances are remarkably similar to those associated with chaotrope-induced water stress. These findings suggest that it may be possible to devise new interventions for microbial processes in both natural environments and industrial reactors to expand microbial tolerance of hydrophobic substances, and hence the biotic windows for such processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.