ReviewMicrobial biotechnology2010
Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens: from identification to application.
Review in Microbial biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis.PLoS genetics · 2025Article
- Recent Research Advances in Small Regulatory RNAs in Streptococcus.Current microbiology · 2021Review
- The Small RNA RyhB Homologs fromMicroorganisms · 2021Article
- The Regulatory RNAFrontiers in microbiology · 2021Article
- RNA-Sequencing Analyses of Small Bacterial RNAs and their Emergence as Virulence Factors in Host-Pathogen Interactions.International journal of molecular sciences · 2020Review
- Article
- The Regulatory Roles of ncRNA Rli60 in Adaptability of Listeria monocytogenes to Environmental Stress and Biofilm Formation.Current microbiology · 2016Article
- In silico prediction and qPCR validation of novel sRNAs inJournal, genetic engineering & biotechnology · 2016Article
- The Mechanisms of Virulence Regulation by Small Noncoding RNAs in Low GC Gram-Positive Pathogens.International journal of molecular sciences · 2015Review
- Review
- Genome-wide analyses of small non-coding RNAs in streptococci.Frontiers in genetics · 2015Review
- Involvement of Enterococcus faecalis small RNAs in stress response and virulence.Infection and immunity · 2014Article
- Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile.PLoS genetics · 2013Article
- Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome.BMC genomics · 2013Article
- Novel regulatory small RNAs in Streptococcus pyogenes.PloS one · 2013Article
- The small regulatory RNA FasX controls pilus expression and adherence in the human bacterial pathogen group A Streptococcus.Molecular microbiology · 2012Article
- sRNAdb: a small non-coding RNA database for gram-positive bacteria.BMC genomics · 2012Article
- The intracellular sRNA transcriptome of Listeria monocytogenes during growth in macrophages.Nucleic acids research · 2011Article
- Identification and Role of Regulatory Non-Coding RNAs inInternational journal of molecular sciences · 2011Review
- Genome-wide identification of small RNAs in the opportunistic pathogen Enterococcus faecalis V583.PloS one · 2011Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the recent years, the number of drug- and multi-drug-resistant microbial strains has increased rapidly. Therefore, the need to identify innovative approaches for development of novel anti-infectives and new therapeutic targets is of high priority in global health care. The detection of small RNAs (sRNAs) in bacteria has attracted considerable attention as an emerging class of new gene expression regulators. Several experimental technologies to predict sRNA have been established for the Gram-negative model organism Escherichia coli. In many respects, sRNA screens in this model system have set a blueprint for the global and functional identification of sRNAs for Gram-positive microbes, but the functional role of sRNAs in colonization and pathogenicity for Listeria monocytogenes, Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis and Clostridium difficile is almost completely unknown. Here, we report the current knowledge about the sRNAs of these socioeconomically relevant Gram-positive pathogens, overview the state-of-the-art high-throughput sRNA screening methods and summarize bioinformatics approaches for genome-wide sRNA identification and target prediction. Finally, we discuss the use of modified peptide nucleic acids (PNAs) as a novel tool to inactivate potential sRNA and their applications in rapid and specific detection of pathogenic bacteria.
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