ArticleMedical mycology2011
Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling.
Article in Medical mycology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Lactic acid in the vaginal milieu modulates theVirulence · 2025Article
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- Innate immune responses against the fungal pathogen Candida auris.Nature communications · 2022Article
- The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation.Medicines (Basel, Switzerland) · 2022Article
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- Fingolimod Potentiates the Antifungal Activity of Amphotericin B.Frontiers in cellular and infection microbiology · 2021Article
- Review
- Candida albicans enhances meropenem tolerance of Pseudomonas aeruginosa in a dual-species biofilm.The Journal of antimicrobial chemotherapy · 2020Article
- Article
- Pathogenesis of Dermatophytosis: Sensing the Host Tissue.Mycopathologia · 2017Review
- Dressed to impress: impact of environmental adaptation on the Candida albicans cell wall.Molecular microbiology · 2015Review
- Novel insights into host-fungal pathogen interactions derived from live-cell imaging.Seminars in immunopathology · 2015Review
- Article
- Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans.International journal of microbiology · 2014Review
- Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages.Eukaryotic cell · 2014Article
- Mannosylation in Candida albicans: role in cell wall function and immune recognition.Molecular microbiology · 2013Review
- Article
- Reporters for the analysis of N-glycosylation in Candida albicans.Fungal genetics and biology : FG & B · 2013Article
- Thriving within the host: Candida spp. interactions with phagocytic cells.Medical microbiology and immunology · 2013Review
- A competitive infection model of hematogenously disseminated candidiasis in mice redefines the role of Candida albicans IRS4 in pathogenesis.Infection and immunity · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The cell wall of the opportunistic human fungal pathogen, Candida albicans is a complex, layered network of rigid structural polysaccharides composed of β-glucans and chitin that is covered with a fibrillar matrix of highly glycosylated mannoproteins. Polymorphonuclear cells (PMNs, neutrophils) are the most prevalent circulating phagocytic leukocyte in peripheral blood and they are pivotal in the clearance of invading fungal cells from tissues. The importance of cell-wall mannans for the recognition and uptake of C. albicans by human PMNs was therefore investigated. N- and O-glycosylation-deficient mutants were attenuated in binding and phagocytosis by PMNs and this was associated with reduced killing of C. albicans yeast cells. No differences were found in the production of the respiratory burst enzyme myeloperoxidase (MPO) and the neutrophil chemokine IL-8 in PMNs exposed to control and glycosylation-deficient C. albicans strains. Thus, the significant decrease in killing of glycan-deficient C. albicans strains by PMNs is a consequence of a marked reduction in phagocytosis rather than changes in the release of inflammatory mediators by PMNs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.