Trial reportWiener klinische Wochenschrift2011
Nutritional supplementation affects postoperative oxidative stress and duration of hospitalization in patients with hip fracture.
Trial report in Wiener klinische Wochenschrift, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Nutritional supplementation for hip fracture aftercare in older people.The Cochrane database of systematic reviews · 2016Pooled it
- The role of perioperative oral nutritional supplementation in elderly patients after hip surgery.Clinical interventions in aging · 2015Pooled it
- Effect of oral taurine on morbidity and mortality in elderly hip fracture patients: a randomized trial.International journal of molecular sciences · 2015Trial
- Nutrition-related clinical laboratory indicators in perioperative management of geriatric hip fractures: a narrative review from risk stratification to precision intervention.Frontiers in nutrition · 2026Review
- Comparison of the predictive value of CONUT, NLR, and PNI for 6-month and 1-year mortality in middle-aged and older adults with hip fractures: a retrospective study.Frontiers in nutrition · 2026Article
- Malnutrition in Older Hip Fracture Patients: Prevalence, Pathophysiology, Clinical Outcomes, and Treatment-A Systematic Review.Journal of clinical medicine · 2025Review
- Threshold effect of prognostic nutritional index on mortality in geriatric hip fracture patients.Scientific reports · 2025Article
- Are we achieving the standards of good nutritional care for older people in hospital with fragility fractures?BMJ open quality · 2023Article
- Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects.Frontiers in aging · 2023Review
- What Postoperative Nutritional Interventions Lead to Better Outcomes in Fragility Hip Fractures? A Systematic Review.Geriatric orthopaedic surgery & rehabilitation · 2023Review
- Efficacy of Oral Nutritional Supplements in Patients Undergoing Surgical Intervention for Hip Fracture.Geriatric orthopaedic surgery & rehabilitation · 2022Article
- Geriatric Nutritional Risk Index and Controlling Nutritional Status Score can predict postoperative 180-day mortality in hip fracture surgeries.JA clinical reports · 2019Article
- The Surgical Apgar Score can help predict postoperative complications in femoral neck fracture patients: a 6-year retrospective cohort study.JA clinical reports · 2018Article
- Nutritional Status and Nutritional Treatment Are Related to Outcomes and Mortality in Older Adults with Hip Fracture.Nutrients · 2018Review
- Amorphous Silica: A New Antioxidant Role for Rapid Critical-Sized Bone Defect Healing.Advanced healthcare materials · 2016Article
- Enhanced interfacial adhesion and osteogenesis for rapid "bone-like" biomineralization by PECVD-based silicon oxynitride overlays.ACS applied materials & interfaces · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this prospective randomized controlled study was to investigate the effect of nutritional supplementation on postoperative oxidative stress and duration of hospitalization in elderly patients with hip fracture.
methodsA total of fourteen women (= SG) with hip fracture received individually adapted supplements enriched with protein and antioxidants postoperatively, nine served as unsupplemented controls (= CG). Blood samples were taken preoperatively (T1), on the day of discharge from hospital (T2) and three weeks thereafter (T3). Plasma concentrations of albumin and total protein (TP) were measured by autoanalysis, advanced oxidation protein products (AOPP) and the total antioxidant capacity (TAC) were determined photometrically. Malondialdehyde (MDA) levels were analyzed by HPLC.
resultsPostoperatively, there was a significant (T1 > T2, p< 0.01) decrease in plasma albumin, TP and TAC, followed by a significant (p< 0.05) increase in the period T2-T3 in the CG, but not in the SG. This resulted in significant differences in TP (T2: SG > CG, p< 0.05) and TAC (T2: SG > CG, p< 0.01) between the investigated groups. Postoperatively, the plasma levels of AOPP and MDA increased significantly (T1 < T2, p< 0.01) in both groups, and remained at the significantly (AOPP: T1 < T3, p< 0.05; MDA: T1 < T3, p< 0.01) elevated level in the CG, but not in the SG (T2 > T3, p< 0.01). Consequently, the oxidant markers MDA and AOPP were significantly positively (p< 0.01), TAC and albumin significantly negatively (p< 0.05) related to duration of hospital stay in both groups.
conclusionsIndividualized nutritional supplementation may reduce postoperative oxidative stress and shorten duration of hospitalization in patients with hip fracture.
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