ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2011
Physiology of aging among healthy, older bottlenose dolphins (Tursiops truncatus): comparisons with aging humans.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Efficient cryopreservation of Antillean manatee skin-derived somatic cells via reduced intracellular cryoprotectant concentration.In vitro cellular & developmental biology. Animal · 2026Article
- Aging-Associated Amyloid-β Plaques and Neuroinflammation in Bottlenose Dolphins (International journal of molecular sciences · 2025Article
- A time-series analysis of blood-based biomarkers within a 25-year longitudinal dolphin cohort.PLoS computational biology · 2023Article
- Article
- Effects of sex, age, and season on the variation of blood analytes in a clinically healthyThe veterinary quarterly · 2020Article
- A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Erythrocyte sedimentation rate and hemoglobin-binding protein in free-living box turtles (Terrapene spp.).PloS one · 2020Article
- Article
- New de novo assembly of the Atlantic bottlenose dolphin (Tursiops truncatus) improves genome completeness and provides haplotype phasing.GigaScience · 2019Article
- Effect of age, sex, and season on the variation in blood analytes of a clinically normal ex situ population of killer whales (Orcinus orca).Veterinary clinical pathology · 2019Article
- Senescence impacts reproduction and maternal investment in bottlenose dolphins.Proceedings. Biological sciences · 2018Article
- Development and testing of species-specific ELISA assays to measure IFN-γ and TNF-α in bottlenose dolphins (Tursiops truncatus).PloS one · 2018Article
- Physiological consequences of biologic state and habitat dynamics on the critically endangered Yangtze finless porpoises (Conservation physiology · 2018Article
- Comparisons of life-history parameters between free-ranging and captive killer whale (Journal of mammalogy · 2015Article
- Dolphins and diabetes: applying one health for breakthrough discoveries.Frontiers in endocrinology · 2014Article
- Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores.Frontiers in endocrinology · 2013Review
- Diabetes and the metabolic syndrome: possibilities of a new breath test in a dolphin model.Frontiers in endocrinology · 2013Review
- Evaluation of potential protective factors against metabolic syndrome in bottlenose dolphins: feeding and activity patterns of dolphins in sarasota bay, Florida.Frontiers in endocrinology · 2013Review
- Identification of Lactobacillus strains with probiotic features from the bottlenose dolphin (Tursiops truncatus).Journal of applied microbiology · 2013Article
- Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia.Frontiers in endocrinology · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in hematological and serum chemistry values have been identified among older compared to younger humans. We hypothesized that healthy bottlenose dolphins (Tursiops truncatus) 30 years and older may demonstrate similar clinicopathological changes with increasing age. Retrospective hematological and serum chemistry data generated from routine, fasted blood samples collected over 10 to 20 years among six healthy dolphins that lived at least 40 years were analyzed to (1) assess linear trends in blood variable values with increasing age, (2) compare mean blood values by older age categories (30-35 years, 36-40 years, and >40 years), and (3) compare the prevalence of clinically high or low blood values by older age categories. Absolute lymphocytes, serum globulins, and mean platelet volume increased linearly with increasing old age. Mean white blood cells, neutrophils, serum globulins, erythrocyte sedimentation rates, serum cholesterol, and serum triglycerides; and the prevalence of neutrophilic leukocytosis, hyperglobulinemia, and hypercholesterolemia, were more likely to be higher as geriatric dolphins got older. A linear decrease in serum albumin with increasing age was present for five of six animals. Serum creatinine decreased among dolphins older than 40 years compared to when they were 30-40 years old. Our study demonstrates that older dolphins have changes in hematological and serum chemistry values similar to those found in older humans. As such, bottlenose dolphins may serve as a useful comparative model for aging in humans. Further studies are needed to assess whether these changes are associated with negative health outcomes and whether targeted therapeutics can help improve quality of life among aging dolphins.
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