ArticlePloS one2011
Increased memory conversion of naïve CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.PLoS pathogens · 2015Article
- The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization.Clinical and experimental immunology · 2014Article
- Loss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection.Viral immunology · 2013Article
- Inflammatory cytokines presented from polymer matrices differentially generate and activate DCsAdvanced functional materials · 2013Article
- Immune mechanisms in malaria: new insights in vaccine development.Nature medicine · 2013Review
- Dynamics of CD4(+) T cell responses against Listeria monocytogenes.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis.Journal of virology · 2012Article
- The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMemory CD8 T cells form an essential part of protective immunity against viral infections. Antigenic load, costimulation, CD4-help, cytokines and chemokines fluctuate during the course of an antiviral immune response thus affecting CD8 T cell activation and memory conversion. METHODOLOGY/PRINCIPAL
findingsIn the present study, naïve TCR transgenic LCMV-specific P14 CD8 T cells engaged at a late stage during the acute antiviral LCMV response showed reduced expansion kinetics but greater memory conversion in the spleen. Such late activated cells displayed a memory precursor effector phenotype already at the peak of the systemic antiviral response, suggesting that the environment determined their fate during antigen encounter. In the spleen, the majority of late transferred cells exhibited a central memory phenotype compared to the effector memory displayed by the early transferred cells. Increasing the inflammatory response by exogenous administration of IFNγ, PolyI:C or CpG did not affect memory conversion in the late transferred group, suggesting that the diverging antigen load early versus later during acute infection had determined their fate. In agreement, reduction in the LCMV antigenic load after ribavirin treatment enhanced the contribution of early transferred cells to the long lasting memory pool. CONCLUSIONS/SIGNIFICANCE: Our results show that naïve CD8 cells, exposed to reduced duration or concentration of antigen during viral infection convert into memory more efficiently, an observation that could have significant implications for vaccine design.
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