ArticlePLoS genetics2011
A novel RNA-recognition-motif protein is required for premeiotic G1/S-phase transition in rice (Oryza sativa L.).
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 66 citations in OpenAlex.
- Premeiotic chromatin states orchestrate gene expression during male gametogenesis in rice.Genome biology · 2026Article
- A staging framework to study rice female gametophyte development.Plant reproduction · 2026Article
- MORE FLORET1 Interacts with C-type Replication Protein A Complex and Regulates Male Meiosis in Rice.Rice (New York, N.Y.) · 2025Article
- RETINOBLASTOMA RELATED 1 switches mitosis to meiosis in rice.Plant communications · 2024Article
- Construction of a Female Sterility Maintaining System Based on a Novel Mutation of the MEL2 Gene.Rice (New York, N.Y.) · 2024Article
- Single-cell RNA-seq of maize meiocytes and pollen grains.Nature protocols · 2023Review
- Genetic Regulation of Mitosis-Meiosis Fate Decision in Plants: Is Callose an Oversighted Polysaccharide in These Processes?Plants (Basel, Switzerland) · 2023Review
- Natural variation in Tiller Number 1 affects its interaction with TIF1 to regulate tillering in rice.Plant biotechnology journal · 2023Article
- Rice GLUCAN SYNTHASE-LIKE5 promotes anther callose deposition to maintain meiosis initiation and progression.Plant physiology · 2023Article
- Overcoming roadblocks forFrontiers in plant science · 2023Review
- 3D cellular morphometrics of ovule primordium development inFrontiers in plant science · 2023Article
- Characterization of germline development and identification of genes associated with germline specification in pineapple.Horticulture research · 2021Article
- Meiosis in crops: from genes to genomes.Journal of experimental botany · 2021Review
- A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis.PLoS genetics · 2021Article
- The Formation of Bivalents and the Control of Plant Meiotic Recombination.Frontiers in plant science · 2021Review
- Transcriptional trajectories of anther development provide candidates for engineering male fertility in sorghum.Scientific reports · 2020Article
- Genome-Wide Association Study for Biomass Related Traits in a Panel ofFrontiers in plant science · 2020Article
- Article
- The OsRR24/LEPTO1 Type-B Response Regulator is Essential for the Organization of Leptotene Chromosomes in Rice Meiosis.The Plant cell · 2018Article
- Stage-Specific Gene Profiling of Germinal Cells Helps Delineate the Mitosis/Meiosis Transition.Plant physiology · 2018Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanism for meiotic entry remains largely elusive in flowering plants. Only Arabidopsis SWI1/DYAD and maize AM1, both of which are the coiled-coil protein, are known to be required for the initiation of plant meiosis. The mechanism underlying the synchrony of male meiosis, characteristic to flowering plants, has also been unclear in the plant kingdom. In other eukaryotes, RNA-recognition-motif (RRM) proteins are known to play essential roles in germ-cell development and meiosis progression. Rice MEL2 protein discovered in this study shows partial similarity with human proline-rich RRM protein, deleted in Azoospermia-Associated Protein1 (DAZAP1), though MEL2 also possesses ankyrin repeats and a RING finger motif. Expression analyses of several cell-cycle markers revealed that, in mel2 mutant anthers, most germ cells failed to enter premeiotic S-phase and meiosis, and a part escaped from the defect and underwent meiosis with a significant delay or continued mitotic cycles. Immunofluorescent detection revealed that T7 peptide-tagged MEL2 localized at cytoplasmic perinuclear region of germ cells during premeiotic interphase in transgenic rice plants. This study is the first report of the plant RRM protein, which is required for regulating the premeiotic G1/S-phase transition of male and female germ cells and also establishing synchrony of male meiosis. This study will contribute to elucidation of similarities and diversities in reproduction system between plants and other species.
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