ArticlePLoS genetics2011
Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome.Journal of neurochemistry · 2025Article
- 3'UTR Diversity: Expanding Repertoire of RNA Alterations in Human mRNAs.Molecules and cells · 2023Review
- Dynamic Variations of 3'UTR Length Reprogram the mRNA Regulatory Landscape.Biomedicines · 2021Review
- Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain.Nature communications · 2021Article
- A Comprehensive Analysis of the Role of hnRNP A1 Function and Dysfunction in the Pathogenesis of Neurodegenerative Disease.Frontiers in molecular biosciences · 2021Review
- Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage.Stem cell reports · 2020Article
- Leveraging mRNA Sequences and Nanoparticles to Deliver SARS-CoV-2 Antigens In Vivo.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Article
- Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses.The Journal of biological chemistry · 2018Article
- Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.RNA (New York, N.Y.) · 2018Article
- Autogenous cross-regulation ofGenes & development · 2017Article
- Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing.Scientific reports · 2017Article
- RNA-binding Protein Quaking StabilizesThe Journal of biological chemistry · 2017Article
- hnRNPA1 autoregulates its own mRNA expression to remain non-cytotoxic.Molecular and cellular biochemistry · 2017Article
- Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.Nature immunology · 2017Article
- The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.Nucleic acids research · 2016Article
- Quaking Regulates Neurofascin 155 Expression for Myelin and Axoglial Junction Maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and β-catenin protein expression.Scientific reports · 2016Article
- A cytoplasmic quaking I isoform regulates the hnRNP F/H-dependent alternative splicing pathway in myelinating glia.Nucleic acids research · 2014Article
- The RNA-binding protein QKI suppresses cancer-associated aberrant splicing.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In mice, Quaking (Qk) is required for myelin formation; in humans, it has been associated with psychiatric disease. QK regulates the stability, subcellular localization, and alternative splicing of several myelin-related transcripts, yet little is known about how QK governs these activities. Here, we show that QK enhances Hnrnpa1 mRNA stability by binding a conserved 3' UTR sequence with high affinity and specificity. A single nucleotide mutation in the binding site eliminates QK-dependent regulation, as does reduction of QK by RNAi. Analysis of exon expression across the transcriptome reveals that QK and hnRNP A1 regulate an overlapping subset of transcripts. Thus, a simple interpretation is that QK regulates a large set of oligodendrocyte precursor genes indirectly by increasing the intracellular concentration of hnRNP A1. Together, the data show that hnRNP A1 is an important QK target that contributes to its control of myelin gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.