ArticlePLoS computational biology2011
Relationships between gene expression and brain wiring in the adult rodent brain.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 147 citations in OpenAlex.
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- A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- BrainConnect: processing brain connectivity and spatial transcriptomics data for integrative analysis.Bioinformatics (Oxford, England) · 2026Article
- Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity.bioRxiv : the preprint server for biology · 2025Article
- Molecular architecture of language-related cortical areas revealed by integrative proteomic and connectome analyses.Clinical and translational medicine · 2025Article
- CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The multiscale brain structural re-organization that occurs from childhood to adolescence correlates with cortical morphology maturation and functional specialization.PLoS biology · 2025Article
- Intrinsic Gene Expression Correlates of the Biophysically Modeled Diffusion Magnetic Resonance Imaging Signal.Biological psychiatry global open science · 2025Article
- Hyperedge overlap drives explosive transitions in systems with higher-order interactions.Nature communications · 2025Article
- The genetics of spatiotemporal variation in cortical thickness in youth.Communications biology · 2024Article
- BrainTACO: an explorable multi-scale multi-modal brain transcriptomic and connectivity data resource.Communications biology · 2024Article
- Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence.Nature communications · 2024Article
- Predicting evolutionary targets and parameters of gene deletion from expression data.Bioinformatics advances · 2024Article
- The neuroanatomical organization of the hypothalamus is driven by spatial and topological efficiency.Frontiers in systems neuroscience · 2024Article
- Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture.Communications biology · 2023Article
- Towards a biologically annotated brain connectome.Nature reviews. Neuroscience · 2023Review
- The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity.PLoS biology · 2023Article
- NeST: nested hierarchical structure identification in spatial transcriptomic data.Nature communications · 2023Article
- Robust estimation of cortical similarity networks from brain MRI.Nature neuroscience · 2023Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We studied the global relationship between gene expression and neuroanatomical connectivity in the adult rodent brain. We utilized a large data set of the rat brain "connectome" from the Brain Architecture Management System (942 brain regions and over 5000 connections) and used statistical approaches to relate the data to the gene expression signatures of 17,530 genes in 142 anatomical regions from the Allen Brain Atlas. Our analysis shows that adult gene expression signatures have a statistically significant relationship to connectivity. In particular, brain regions that have similar expression profiles tend to have similar connectivity profiles, and this effect is not entirely attributable to spatial correlations. In addition, brain regions which are connected have more similar expression patterns. Using a simple optimization approach, we identified a set of genes most correlated with neuroanatomical connectivity, and find that this set is enriched for genes involved in neuronal development and axon guidance. A number of the genes have been implicated in neurodevelopmental disorders such as autistic spectrum disorder. Our results have the potential to shed light on the role of gene expression patterns in influencing neuronal activity and connectivity, with potential applications to our understanding of brain disorders. Supplementary data are available at http://www.chibi.ubc.ca/ABAMS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.