Evidence map›Paper›PMID 21253536›Full record

ArticleHepatitis research and treatment2010

Xenobiotic exposure and autoimmune hepatitis.

Kathleen M Gilbert

Open access · hybridAbstract read
In one paragraph

Article in Hepatitis research and treatment, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors.International journal of environmental research and public health · 2021
    Review
  4. Review
  5. Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis.Toxicological sciences : an official journal of the Society of Toxicology · 2017
    Article
  6. Pretreatment with TCDD exacerbates liver injury from Concanavalin A: critical role for NK cells.Toxicological sciences : an official journal of the Society of Toxicology · 2013
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kathleen M GilbertArkansas Children's Hospital Research Institute, University of Arkansas for Medical Sciences, 13 Children's Way, Little Rock, AR 72202, USA.
Arkansas Children's Hospital · US

Funding

Determining how trichloroethylene alters CD4+ T cell functionR01ES017286 · NIEHS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI GILBERT, KATHLEEN M · 2010 to 2012
$991k
NIEHS NIH HHS R01 ES017286
6 · The paper itself

Abstract

Although genetics contributes to the development of autoimmune diseases, it is clear that "environmental" factors are also required. These factors are thought to encompass exposure to certain drugs and environmental pollutants. This paper examines the mechanisms that normally maintain immune unresponsiveness in the liver and discusses how exposure to certain xenobiotics such as trichloroethylene may disrupt those mechanisms and promote autoimmune hepatitis.

Identifiers

PMID21253536
PMCPMC3021850
OpenAlexW2154136629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.