ArticleJournal of obesity2011
Gene by sex interaction for measures of obesity in the framingham heart study.
Article in Journal of obesity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.PloS one · 2014Pooled it
- Sex Differences in Obesity and Cognitive Function in Chinese Elderly Patients With Chronic Schizophrenia.Frontiers in endocrinology · 2022Article
- Genome-wide association study of morbid obesity in Han Chinese.BMC genetics · 2019Article
- Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones.Communications biology · 2018Review
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- Article
- Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.Circulation · 2015Article
- Sex- and age-interacting eQTLs in human complex diseases.Human molecular genetics · 2014Article
- Development and evaluation of a genetic risk score for obesity.Biodemography and social biology · 2013Article
- Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases.Journal of lipid research · 2012Article
- Early-onset obesity and the unwanted promise of thrombosis.Journal of thrombosis and thrombolysis · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.