Evidence map›Paper›PMID 21253495›Full record

ArticleAdvances in hematology2011

Pathobiology of hodgkin lymphoma.

Pier Paolo Piccaluga, Claudio Agostinelli, Anna Gazzola, Claudio Tripodo, Francesco Bacci, Elena Sabattini, Maria Teresa Sista, Claudia Mannu, Maria Rosaria Sapienza, Maura Rossi and 4 more

Abstract read
In one paragraph

Article in Advances in hematology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. The role of immunohistochemistry in the assessment of classical Hodgkin lymphoma microenvironment.International journal of clinical and experimental pathology · 2022
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future.International journal of molecular sciences · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Clinical characteristics of 26 patients with primary extranodal Hodgkin lymphoma.International journal of clinical and experimental pathology · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pier Paolo PiccalugaHematopathology Section, Department of Hematology and Oncological Sciences "L. and A. Seràgnoli", S. Orsola-Malpighi Hospital, University of Bologna, 40126 Bologna, Italy.
Claudio Agostinelli
Anna Gazzola
Claudio Tripodo
Francesco Bacci
Elena Sabattini
Maria Teresa Sista
Claudia Mannu
Maria Rosaria Sapienza
Maura Rossi
Maria Antonella Laginestra
Carlo A Sagramoso-Sacchetti
Simona Righi
Stefano A Pileri

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (cHL), reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molecular features. cHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between cHL and anaplastic large-cell lymphoma have become sharper, whereas those between LP-HL and T-cell-rich B-cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumor in at-risk patients have been proposed and are on the way to being applied.

Identifiers

PMID21253495
PMCPMC3021869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.