ArticlePathology research international2011
Circulating tumor cells in breast cancer patients: an evolving role in patient prognosis and disease progression.
Article in Pathology research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Circulating Tumor Cells: Emerging Frontiers in Cancer Technology.Expert reviews in molecular medicine · 2026Review
- Detection of circulating tumour cells in colorectal cancer: Emerging techniques and clinical implications.World journal of clinical oncology · 2021Review
- EMT-independent detection of circulating tumor cells in human blood samples and pre-clinical mouse models of metastasis.Clinical & experimental metastasis · 2021Article
- The increased adhesion of tumor cells to endothelial cells after irradiation can be reduced by FAK-inhibition.Radiation oncology (London, England) · 2019Article
- The Significance of Epithelial-to-Mesenchymal Transition for Circulating Tumor Cells.International journal of molecular sciences · 2016Review
- Assessment of Cytokeratin-19 Gene Expression in Peripheral Blood of Breast Cancer Patients and Breast Cancer Cell Lines.Biomarkers in cancer · 2016Article
- Article
- A microfluidic model for organ-specific extravasation of circulating tumor cells.Biomicrofluidics · 2014Article
- Detection of Circulating Tumour Cells from Blood of Breast Cancer Patients via RT-qPCR.Cancers · 2013Article
- Mechanisms of Metastatic Tumor Dormancy.Journal of clinical medicine · 2013Review
- Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.The Journal of clinical investigation · 2013Article
- A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire.International journal of oncology · 2012Article
- Dynamics of circulating tumor cells in early breast cancer under neoadjuvant therapy.Experimental and therapeutic medicine · 2012Article
- Circulating Tumor Cells Detected by RT-PCR for CK-20 before Surgery Indicate Worse Prognostic Impact in Triple-Negative and HER2 Subtype Breast Cancer.Journal of breast cancer · 2012Article
- Circulating Tumor Cells Detection in Patients with Early Breast Cancer Using MACS Immunomagnetic Flow Cytometry.Avicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In this paper, we examine the role of circulating tumor cells (CTCs) in breast cancer. CTCs are tumor cells present in the peripheral blood. They are found in many different carcinomas but are not present in patients with benign disease. Recent advances in theories regarding metastasis support the role of early release of tumor cells in the neoplastic process. Furthermore, it has been found that phenotypic variation exists between the primary tumor and CTCs. Of particular interest is the incongruency found between primary tumor and CTC HER2 status in both metastatic and early breast cancer. Overall, CTCs have been shown to be a poor prognostic marker in metastatic breast cancer. CTCs in early breast cancer are not as well studied, however, several studies suggest that the presence of CTCs in early breast cancer may also suggest a poorer prognosis. Studies are currently underway looking at the use of CTC level monitoring in order to guide changes in therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.