Evidence map›Paper›PMID 21253423›Full record

ArticleThe Korean journal of hematology2010

The immunobiology of cord blood transplantation.

Paul Szabolcs

Abstract read
In one paragraph

Article in The Korean journal of hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul SzabolcsDepartment of Pediatrics, Pediatric Blood and Marrow Transplant Program and Department of Immunology, Duke University, Durham, USA.

Funding

Preclinical studies of unrelated cord blood transplantationP01HL067314 · NHLBI · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2002 to 2005
$6.9M
Graft Engineering and Immunotherapy After Unrelated Cord Blood TransplantationR01CA132110 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SZABOLCS, PAUL · 2007 to 2011
$1.5M
NCI NIH HHS R01 CA132110NHLBI NIH HHS P01 HL067314
6 · The paper itself

Abstract

Despite significant recent advances in the applicability and outcome following unrelated cord blood transplantation (UCBT), infections remain a major cause of mortality associated with poor immune recovery in the first 6 months after UCBT. Enhanced immune reconstitution not only could improve survival by reduced transplant related mortality, but may also favorably impact on relapse incidence by improved graft-versus-leukemia effects. This review will summarize our current understanding of the biology of immune recovery post-UCBT with an emphasis on adaptive T cell dependent immunity. New efforts to boost immunity will be also highlighted including our own laboratory, where ex vivo T cell expansion is pursued towards adoptive immunotherapy.

Indexed as

Adoptive immunotherapyCord blood stem cell transplantationGraft vs leukemia effectImmune reconstitutionOpportunistic infection

Identifiers

PMID21253423
PMCPMC3023047

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.