ArticleWorld journal of gastroenterology2011
Liver function alterations after laparoscopy-assisted gastrectomy for gastric cancer and its clinical significance.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02013596 (Effect of Transcutaneous Electrical Acupoint Stimulation), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Transcutaneous Electrical Acupoint Stimulation(TEAS) on the Hepatic and Renal Function Impaired by Pneumoperitoneum: a Prospective, Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Effect of Subanesthetic Dose of Esketamine on Liver Function Following Microvascular Reconstruction for Head and Neck Cancer: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- A silicone disc for liver retraction in laparoscopic gastrectomy reduces the postoperative increase in the liver enzyme level.Surgery today · 2024Trial
- Hiatal sling liver retraction technique in bariatric and upper gastrointestinal surgeries - Our 15 year experience with 1874 surgeries.Journal of minimal access surgery · 2026Article
- Transient liver enzyme elevations following laparoscopic cholecystectomy: a comprehensive review.Updates in surgery · 2025Review
- Postoperative liver dysfunction in gastric cancer patients following early enhanced nutritional protocols: a retrospective observational study.Journal of pharmaceutical health care and sciences · 2025Article
- Evaluating liver function test alterations in laparoscopic right adrenalectomy with different retractors.Northern clinics of Istanbul · 2025Article
- Risk factors for liver dysfunction and their clinical importance after gastric cancer surgery.Scientific reports · 2024Article
- Influence of liver function after laparoscopy-assistedWorld journal of gastrointestinal surgery · 2023Article
- Clinical significance of aberrant left hepatic artery during gastrectomy: A systematic review.World journal of clinical cases · 2022Article
- Comparison of the Pretzelflex Retractor and Nathanson Retractor in Laparoscopic Sleeve Gastrectomy Surgery.Obesity surgery · 2021Article
- A Novel Technique to Predict Liver Damage After Laparoscopic Gastrectomy From the Stomach Volume Overlapping the Liver by Preoperative Computed Tomography.World journal of surgery · 2020Article
- Novel use of the Nathanson liver retractor to prevent postoperative transient liver dysfunction during laparoscopic gastrectomy.Asian journal of endoscopic surgery · 2020Article
- Comparison of Two Types of Liver Retractors in Laparoscopic Roux-en-Y Gastric Bypass for Morbid Obesity.Obesity surgery · 2020Article
- Intractable hyperkalemia caused by hepatic infarction developed during laparoscopic gastrectomy in a patient with end-stage renal failure: a case report.JA clinical reports · 2019Article
- Study of celiac artery variations and related surgical techniques in gastric cancer.World journal of gastroenterology · 2015Article
- Cardiac and Liver Marker Alterations After Laparoscopic Gynaecologic Operations.Turkish journal of anaesthesiology and reanimation · 2015Article
- Effect of pneumoperitoneum on the recovery from intense neuromuscular blockade by rocuronium in healthy patients undergoing laparoscopic surgery.Korean journal of anesthesiology · 2014Article
- Elevation of liver function tests after laparoscopic gastrectomy using a Nathanson liver retractor.World journal of surgery · 2011Article
- Volume change of segments II and III of the liver after gastrectomy in patients with gastric cancer.Diagnostic and interventional radiology (Ankara, Turkey)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the factors associated with liver function alterations after laparoscopy-assisted gastrectomy (LAG) for gastric cancer.
methodsWe collected the data of gastrectomy patients with gastric cancer and divided them into 2 groups: open gastrectomy (OG) and LAG. We also collected the data of patients with colon cancer to evaluate the effect of liver manipulations during surgery on liver function alterations. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and alkaline phosphatase were measured on the preoperative day and postoperative day 1 (POD1), POD3, POD5, and POD7.
resultsNo changes in liver function were observed after the operation in patients with colon cancer (n = 121). However, in gastric cancer patients (n = 215), AST and ALT levels increased until POD5 compared to those in colon cancer patients and these findings were observed both in the LAG and OG without a significant difference except at POD1. The mean hepatic enzyme levels at POD1 in the LAG group were significantly higher than those in the OG group (P = 0.047 for AST and P = 0.039 for ALT). The factors associated with elevated ALT on POD1 in patients with gastric cancer were body mass index (P < 0.001), operation time (P < 0.001), intraoperative hepatic injury (P = 0.048), and ligation of an aberrant left hepatic artery (P = 0.052) but not type of operation (OG vs LAG, P = 0.094).
conclusionWe conclude that the liver function alteration after LAG may have been caused by direct liver manipulation or aberrant hepatic artery ligation rather than the CO₂ pneumoperitoneum.
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