ArticleThe Journal of cell biology1990
Actin filament nucleation by the bacterial pathogen, Listeria monocytogenes.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 133 citations in OpenAlex.
- Divergent roles of β- and γ-actin isoforms during spread of vaccinia virus.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Article
- Listeria monocytogenes spreads within the brain by actin-based intra-axonal migration.Infection and immunity · 2015Article
- Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Three-dimensional architecture of actin filaments in Listeria monocytogenes comet tails.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Yogi Berra, Forrest Gump, and the discovery of Listeria actin comet tails.Molecular biology of the cell · 2012Article
- Building distinct actin filament networks in a common cytoplasm.Current biology : CB · 2011Review
- Animal cell hydraulics.Journal of cell science · 2009Article
- In silico reconstitution of actin-based symmetry breaking and motility.PLoS biology · 2009Article
- The Key Events Dose-Response Framework: its potential for application to foodborne pathogenic microorganisms.Critical reviews in food science and nutrition · 2009Article
- The posttranslocation chaperone PrsA2 contributes to multiple facets of Listeria monocytogenes pathogenesis.Infection and immunity · 2009Article
- Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection.Genetics · 2008Article
- A defective Th1 response of the spleen in the initial phase may explain why splenectomy helps prevent a Listeria infection.Clinical and experimental immunology · 2005Article
- A novel mutation within the central Listeria monocytogenes regulator PrfA that results in constitutive expression of virulence gene products.Journal of bacteriology · 2004Article
- Glutamate transporter cluster formation in astrocytic processes regulates glutamate uptake activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Phagosome maturation: aging gracefully.The Biochemical journal · 2002Review
- Actin-based motility of intracellular microbial pathogens.Microbiology and molecular biology reviews : MMBR · 2001Review
- Ultrastructure of Rickettsia rickettsii actin tails and localization of cytoskeletal proteins.Infection and immunity · 2000Article
- Sequence variations within PrfA DNA binding sites and effects on Listeria monocytogenes virulence gene expression.Journal of bacteriology · 2000Article
- Listeria monocytogenes exploits normal host cell processes to spread from cell to cell.The Journal of cell biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Shortly after Listeria is phagocytosed by a macrophage, it dissolves the phagosomal membrane and enters the cytoplasm. 1 h later, actin filaments coat the Listeria and then become rearranged to form a tail with which the Listeria moves to the macrophage surface as a prelude to spreading. If infected macrophages are treated with cytochalasin D, all the actin filaments associated with the Listeria break down leaving a fine, fibrillar material that does not decorate with subfragment 1 of myosin. This material is associated with either the surface of the Listeria (the cloud stage) or one end (the tail stage). If the cytochalasin-treated infected macrophages are detergent extracted and then incubated in nuclei-free monomeric actin under polymerizing conditions, actin filaments assemble from the fine, fibrillar material, the result being that each Listeria has actin filaments radiating from its surface like the spokes of a wheel (cloud form) or possesses a long tail of actin filaments formed from the fine, fibrillar material located at one end of the Listeria. Evidence that the fine fibrillar material is involved in nucleating actin assembly comes from a Listeria mutant. Although the mutant replicates at a normal rate in macrophages, actin filaments do not form on its surface (cloud stage) or from one end (tail stage), nor does the bacterium spread. Furthermore it does not form the fine fibrillar material. Evidence that the nucleating material is a secretory product of Listeria and not the macrophage comes from experiments using chloramphenicol, which inhibits protein synthesis in Listeria but not in macrophages. If chloramphenicol is applied 1 h after infection, a time before actin filaments are found attached to the Listeria in untreated macrophages, actin filaments never assemble on the Listeria even when fixed 3 h later. Furthermore the fine fibrillar material is absent, although there is a coat of dense granular material.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.