ArticleJournal of perinatology : official journal of the California Perinatal Association2011
Gastrointestinal complications associated with ibuprofen therapy for patent ductus arteriosus.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Use of NSAIDs and acetaminophen and risk of spontaneous intestinal perforations in premature infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Efficacy and Safety of Paracetamol for Patent Ductus Arteriosus Closure in Preterm Infants: An Updated Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2019Pooled it
- Trial
- Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial.PloS one · 2013Trial
- Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Comparison of the effect of continuous and standard intermittent bolus paracetamol infusion on patent ductus arteriosus.European journal of pediatrics · 2021Article
- Comparative effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus.Early human development · 2015Article
- Prolonged persistent patent ductus arteriosus: potential perdurable anomalies in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2012Article
- Patent ductus arteriosus in premature neonates.Drugs · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review intestinal complications associated with ibuprofen treatment of patent ductus arteriosus (PDA). STUDY
designData from preterm infants treated with ibuprofen were retrospectively reviewed. χ(2) test and Fischer's exact test were used for univariate analyses. Multivariate analyses with logistic regression modeling were used to identify risk factors.
resultOne hundred and two infants were treated with ibuprofen for PDA. Nine (9/102, 8.8%) infants developed spontaneous intestinal perforation (SIP), whereas 93/102 (91.2%) did not. The mean (± s.d.) gestational age (GA) at birth in infants with and without SIP was 25.2 (± 1.3) vs 27.6 (± 2.4) weeks (P=0.02) and the median (interquartile) length of stay (LOS) was 109.5 (91.0 to 116.5) vs 75.0 (53.0 to 94.5) days (P=0.002), respectively. The mean (± s.d.) age at starting ibuprofen was 3.3 (± 1.3) vs 5.8 (± 3.5) days in infants with and without SIP, respectively (P=0.03). In logistic regression analyses, increasing GA and later initiation of ibuprofen treatment were protective against risk of SIP; odds ratio, 95% confidence interval (OR, 95% CI)=0.26 (0.09 to 0.75), P=0.01 and 0.63 (0.41 to 0.95), P=0.03, respectively.
conclusionInfants at lower GA are at risk of SIP when treated early with ibuprofen for symptomatic PDA.
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Registered trials
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