Evidence map›Paper›PMID 21252964›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2011

Red blood cell transfusion, feeding and necrotizing enterocolitis in preterm infants.

M El-Dib, S Narang, E Lee, A N Massaro, H Aly

3 registry-linked trialsAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01628133 completednot on this map

Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Infants

TypeobservationalSponsorSt. Louis UniversityRan2011 to 2014Enrolled25ConditionsIntestinal Blood FlowArmsultrasound
NCT01735552 terminatednot on this mapstarted 2012, after this paper: background citation

Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates.

TypeobservationalSponsorUniversity of UtahRan2012 to 2015Enrolled12ConditionsAnemia of Prematurity, Necrotizing Enterocolitis
NCT01735578 completednot on this mapstarted 2012, after this paper: background citation

Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis

TypeobservationalSponsorUniversity of UtahRan2012 to 2015Enrolled52ConditionsAnemia of Prematurity, Necrotizing Enterocolitis
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Observational
  12. Article
  13. A case of transfusion-associated necrotizing enterocolitis in neonates.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  14. Observational
  15. Article
  16. Review
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  20. Relationship of Necrotizing Enterocolitis Rates to Adoption of Prevention Practices in US Neonatal Intensive Care Units.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M El-DibDepartment of Pediatrics, The George Washington University, Children's National Medical Center, Washington, DC 20037, USA.
S Narang
E Lee
A N Massaro
H Aly

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePreliminary studies suggested an association between red blood cell (RBC) transfusion and necrotizing enterocolitis (NEC) in premature neonates. An advantageous effect of withholding feeds during transfusion has never been studied. We aimed, first, to determine whether preterm infants who developed NEC were more likely to be transfused in the 48 to 72 h before the diagnosis of NEC; second, to test if a strict policy of withholding feeds during transfusion would decrease the incidence of transfusion-associated NEC. STUDY

designThe study was conducted in two phases. Phase 1: a retrospective case-control study of premature low-birth weight (<32 weeks and <2500 g) infants who developed NEC over a 6-year period. Phase 2: a comparison study of the incidence of NEC during the 18-months preceding, and the 18 months following the change of practice to withholding feeds during RBC transfusion.

resultIn the case-control study (25 infants with NEC and 25 controls), more infants in the NEC group received transfusions in the 48 and 72 h preceding diagnosis (56 vs 20% within 48 h, P=0.019; and 64 vs 24% within 72 h, P=0.01). The total number of transfusions and age of RBCs were not different between the two groups. Implementing the policy of withholding feeds during transfusion was associated with a decrease in the incidence of NEC from 5.3 to 1.3% (P=0.047).

conclusionInfants who developed NEC frequently received RBC transfusions in the 48 and 72 h preceding presentation of NEC. A strict policy of withholding feeds during transfusion may have a protective effect from NEC.

Indexed as

Case-Control StudiesChild, PreschoolEnterocolitis, NecrotizingErythrocyte TransfusionFemaleGestational AgeHumansIncidenceInfantInfant, NewbornMaleRetrospective Studies

Identifiers

PMID21252964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.