Trial reportJournal of perinatology : official journal of the California Perinatal Association2011
Propofol versus midazolam for intubating preterm neonates: a randomized controlled trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Evaluation of the safety of using propofol for paediatric procedural sedation: A systematic review and meta-analysis.Scientific reports · 2019Pooled it
- Sedation of newborn infants for the INSURE procedure, are we sure?BioMed research international · 2013Pooled it
- Trial
- Premedication before laryngoscopy in neonates: Evidence-based statement from the French society of neonatology (SFN).Frontiers in pediatrics · 2022Review
- Assessing Neonatal Pain with NIPS and COMFORT-B: Evaluation of NICU's Staff Competences.Pain research & management · 2022Article
- Premedication with intravenous midazolam for neonatal endotracheal intubation: A double blind randomized controlled trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery.Frontiers in pediatrics · 2019Article
- Remifentanil: applications in neonates.Journal of anesthesia · 2016Review
- Clinical pharmacology of midazolam in neonates and children: effect of disease-a review.International journal of pediatrics · 2014Review
- Premedication for neonatal intubation: which medications are recommended and why.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe ideal combination of premedication for neonatal tracheal intubation has not been established. The aim of this preliminary study was to compare the intubation conditions between propofol and midazolam as premedication for tracheal intubation in neonates. STUDY
designA double-blinded, randomized, controlled trial was performed, and 20 preterm neonates (28 to 34 week) underwent tracheal intubation following the use of remifentanil associated to either propofol (n = 10) or midazolam (n = 10). Intubation conditions were scored according to a four-point scale.
resultAccording to the main outcome measured (identification of a 50% difference in the intubation conditions), there were no differences regarding the number of attempts and the overall intubation conditions among the groups (P = 1.00).
conclusionBoth combinations of premedications have no differences regarding the quality of intubation, which could be of clinical interest. Besides midazolam, propofol could be a valid alternative as hypnotic for premedication for endotracheal intubation in neonates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.