Evidence map›Paper›PMID 21252960›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2011

Regional tissue oxygenation in preterm born infants in association with echocardiographically significant patent ductus arteriosus.

A Petrova, M Bhatt, R Mehta

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03723889 (Effect of Patent Ductus Arteriosus on Splanchnic Oxygenation at Enteral Feeding Introduction in Preterm Infants), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03723889 completednot on this mapstarted 2013, after this paper: background citation

Effect of Patent Ductus Arteriosus on Splanchnic Oxygenation at Enteral Feeding Introduction in Preterm Infants

TypeobservationalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2013 to 2016Enrolled50ConditionsPatent Ductus Arteriosus
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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  10. A narrative review of the clinical applications of renal NIRS and integration with cerebral NIRS in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

A PetrovaDepartment of Pediatrics, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903-0019, USA. petroran@umdnj.edu
M Bhatt
R Mehta
Johnson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the levels of regional tissue oxygenation in preterm infants in association with echocardiographically significant patent ductus arteriosus (PDA). STUDY

designPreterm infants with gestational age less than 32 week were enrolled before the first dose of the pharmacological treatment for the PDA. Non-invasive near-infrared spectroscopy (NIRS) technology was utilized to measure cerebral (rSO(2)-C), renal (rSO(2)-R) and mesenteric (rSO(2-M)) tissue oxygenation for approximately 60 min. Regional fractional oxygen extraction (FOE) was calculated using simultaneously measured arterial saturation (SaO(2)). We analyzed regional tissue oxygenation and oxygen extraction, hemodynamic parameters, and demographic and clinical information in association with the size of the PDA (moderate vs large).

resultAmong the 38 enrolled infants, the majority were diagnosed with a large (63.2%, n=24) and the rest with a moderate-sized PDA. Infants with large and moderate PDA were comparable in terms of gestational age, study age and weight, mode of delivery and hemodynamic parameters. A significantly higher proportion of infants with a moderate PDA were mechanically ventilated as compared with those with a large PDA. We found no significant differences in the rSO(2)-C and rSO(2)-R, irrespective of the type of respiratory support. However, in infants with a large PDA on continuous nasal positive airway pressure (NCPAP), the rSO(2)-M was lower and mesenteric FOE was higher than that in mechanically ventilated neonates with a large PDA, and in those with moderate PDA irrespective of the type of respiratory support.

conclusionThe PDA size did not affect cerebral and renal tissue oxygenation, but the mesenteric tissue oxygenation was decreased in infants with a large PDA on NCPAP.

Indexed as

Infant, PrematureAnalysis of VarianceCerebrovascular CirculationCohort StudiesCyclooxygenase InhibitorsDuctus Arteriosus, PatentEchocardiography, DopplerFemaleGestational AgeHemodynamicsHumansInfant, NewbornMaleOxygen ConsumptionPredictive Value of TestsPregnancyCyclooxygenase Inhibitors

Identifiers

PMID21252960
OpenAlexW1987297357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.