ReviewCurrent opinion in pediatrics2011
Biomarkers for the early detection of acute kidney injury.
Review in Current opinion in pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04759599 (Which is Better), which is not on this map. Cited by 136 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Which is Better: Narrow vs. Wide Focus for Shock Wave Lithotripsy of Renal Stones
Who cites it
136 citing papers in PubMed, 7 syntheses or guidelines pooled it, 278 citations in OpenAlex.
- Post-asphyxia acute kidney injury in neonates: a systematic review.European journal of pediatrics · 2026Pooled it
- Risk factors for acute kidney injury in Chinese patients with lupus nephritis: a meta-analysis.BMC nephrology · 2026Pooled it
- Biomarker for renal scarring screening in children with vesicoureteral reflux: a systematic review.Frontiers in pediatrics · 2025Pooled it
- The application of machine learning in predicting post-cardiac surgery acute kidney injury in pediatric patients: a systematic review.Frontiers in pediatrics · 2025Pooled it
- The efficacy of novel biomarkers for the early detection and management of acute kidney injury: A systematic review.PloS one · 2025Pooled it
- Comparison of urine neutrophil gelatinase-associated lipocalin and interleukin-18 in prediction of acute kidney injury in adults.Medicine · 2018Pooled it
- Performance of urinary liver-type fatty acid-binding protein in acute kidney injury: a meta-analysis.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Pooled it
- Effect of access sheath diameter used in percutaneous nephrolithotomy on renal function: a prospective randomized study.Urolithiasis · 2024Trial
- Trial
- Acute kidney injury after using contrast during cardiac catheterization in children with heart disease.Journal of Korean medical science · 2014Trial
- Trial
- Biomarkers for early detection of sickle nephropathy.American journal of hematology · 2011Trial
- External validation of the renal angina index for early prediction of severe acute kidney injury in critically ill children: a prospective cohort study from Vietnam.Pediatric nephrology (Berlin, Germany) · 2026Article
- Bayesian-Estimated Vancomycin AUC24 as a Near-Term Renal Risk Signal after Therapeutic Drug Monitoring: A Multicenter Cohort Study.Journal of clinical pharmacology · 2026Article
- Keller/eGFR ratio as a simple and useful tool to make a first differentiation between renal aging and chronic nephropathy in large populations.International urology and nephrology · 2026Review
- Critical care considerations in rhabdomyolysis-associated acute kidney injury and kidney replacement therapy.World journal of nephrology · 2026Review
- Acute renal angina index: a tool for predicting acute kidney injury in the pediatric emergency room.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Evidence-Based Assessment of Pesticide-Related Nephrotoxicity: Clinical Outcomes, Experimental Data, and Molecular Signatures.International journal of molecular sciences · 2026Review
- Machine Learning-Based Prediction and Feature Attribution Analysis of Contrast-Associated Acute Kidney Injury in Patients with Acute Myocardial Infarction.Medicina (Kaunas, Lithuania) · 2026Article
- Urinary biomarkers of diabetic kidney disease.World journal of diabetes · 2026Review
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewAcute kidney injury (AKI) is a common and serious condition, the diagnosis of which depends on serum creatinine, which is a delayed and unreliable indicator of AKI. Fortunately, understanding the early stress response of the kidney to acute injuries has revealed a number of potential biomarkers. The current status of the most promising of these novel AKI biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver-type fatty acid binding protein (L-FABP), and interleukin (IL)-18, is reviewed. RECENT
findingsIn particular, NGAL is emerging as an excellent biomarker in the urine and plasma, for the early prediction of AKI, for monitoring clinical trials in AKI, and for the prognosis of AKI in several common clinical scenarios. However, biomarker combinations may be required to improve our ability to predict AKI and its outcomes in a context-specific manner. SUMMARY: It is vital that additional large future studies demonstrate the association between biomarkers and hard clinical outcomes independent of serum creatinine concentrations and that randomization to a treatment for AKI based on high biomarker levels results in an improvement in clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.