Evidence map›Paper›PMID 21252656›Full record

ReviewCurrent opinion in hematology2011

Treatment-related myelodysplastic syndrome: molecular characteristics and therapy.

Ravi Bhatia, H Joachim Deeg

Abstract readReview
In one paragraph

Review in Current opinion in hematology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Myelodysplastic syndromes: diagnosis, prognosis, and treatment.Deutsches Arzteblatt international · 2013
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ravi BhatiaDivision of Hematopoietic Stem Cell and Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA. rbhatia@coh.org
H Joachim Deeg
City of Hope · US

Funding

Transplant for Lymphoma:Therapy-Related LeukemiaP50CA107399 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI FORMAN, STEPHEN J, KWAK, LARRY W · 2004 to 2022
$35.5M
UNRELATED AND HLA-MISMATCHED RELATED DONOR TRANSPLANTSP01HL036444 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RAWLINGS, DAVID J · 1986 to 2010
$25.9M
Abnormalities in gene expression in therapy-related MDSR01HL083050 · NHLBI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI BHATIA, RAVI · 2005 to 2008
$2.3M
NCI NIH HHS P50 CA107399NCI NIH HHS P50CA107399NHLBI NIH HHS P01 HL036444NHLBI NIH HHS P01HL036444NHLBI NIH HHS R01 HL083050NHLBI NIH HHS R01HL083050
6 · The paper itself

Abstract

purpose of reviewTreatment-related myelodysplastic syndrome (t-MDS) is a serious complication of cancer treatment. Here we review recent advances in knowledge of the risk factors, pathogenesis, and treatment of t-MDS. RECENT

findingsRecent studies have provided important new information regarding genetic risk factors that may predispose individual patients to develop t-MDS after exposure to cytotoxic therapeutic agents and that may be used to predict individuals at enhanced risk for this complication. The role of specific candidate genes associated with commonly involved genetic lesions in the pathogenesis of t-MDS has also been investigated. Finally, factors determining outcomes of transplantation treatment for this disorder have been elucidated. Hematopoietic cell transplantation provides potentially curative therapy for t-MDS, but additional improvements are necessary to improve outcomes. SUMMARY: Improved understanding of genetic risk factors is expected to facilitate early identification of patients at risk for t-MDS, guiding therapeutic decision making, and allowing early application of preventive or therapeutic strategies.

Indexed as

Drug-Related Side Effects and Adverse ReactionsChromosome AberrationsGene Expression ProfilingGenetic Predisposition to DiseaseHematopoietic Stem Cell TransplantationHumansMyelodysplastic SyndromesTransplantation, Homologous

Identifiers

PMID21252656
PMCPMC3437333
OpenAlexW1984387339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.