ArticleProceedings of the National Academy of Sciences of the United States of America2011
Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Association between maternal nutritional status in pregnancy and offspring cognitive function during childhood and adolescence; a systematic review.BMC pregnancy and childbirth · 2016Pooled it
- Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.Science (New York, N.Y.) · 2019Trial
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- Moderate maternal nutrient restriction alters type II alveolar epithelial cell density in the non-human primate fetal lung.Experimental physiology · 2026Article
- Poverty and caregiver mental health are related to infant and toddler resting-state brain networks: insights from fNIRS.Neurophotonics · 2026Article
- Fetal Cerebral Blood Flow (Dys)autoregulation.Diagnostics (Basel, Switzerland) · 2025Review
- Requests for support by pregnant women with eating disorder symptoms: a systematic literature review of qualitative studies.Journal of eating disorders · 2025Review
- Maternal under-nutrition during pregnancy alters the molecular response to over-nutrition in multiple organs and tissues in nonhuman primate juvenile offspring.Journal of developmental origins of health and disease · 2024Article
- Diet quality during pregnancy, adolescent brain morphology, and cognitive performance in a population-based cohort.The American journal of clinical nutrition · 2024Article
- Unraveling the Molecular Mechanisms of the Neurodevelopmental Consequences of Fetal Protein Deficiency: Insights From Rodent Models and Public Health Implications.Biological psychiatry global open science · 2024Review
- Association between daily breakfast habit during pregnancy and neurodevelopment in 3-year-old offspring: The Japan Environment and Children's Study.Scientific reports · 2024Article
- Virtual Ontogeny of Cortical Growth Preceding Mental Illness.Biological psychiatry · 2022Article
- Are Brain and Cognitive Reserve Shaped by Early Life Circumstances?Frontiers in neuroscience · 2022Review
- Maternal Nutrition and Neurodevelopment: A Scoping Review.Nutrients · 2021Article
- IGFBP-1 hyperphosphorylation in response to nutrient deprivation is mediated by activation of protein kinase Cα (PKCα).Molecular and cellular endocrinology · 2021Article
- Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-Human Primate.Nutrients · 2021Article
- Genetic vulnerability of exposures to antenatal maternal treatments in 1- to 2-month-old infants.Infancy : the official journal of the International Society on Infant Studies · 2021Article
- Review
- The nonhuman primate hypothalamo-pituitary-adrenal axis is an orchestrator of programming-aging interactions: role of nutrition.Nutrition reviews · 2020Review
- Effects of maternal stress and nutrient restriction during gestation on offspring neuroanatomy in humans.Neuroscience and biobehavioral reviews · 2020Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Moderate maternal nutrient restriction during pregnancy occurs in both developing and developed countries. In addition to poverty, maternal dieting, teenage pregnancy, and uterine vascular problems in older mothers are causes of decreased fetal nutrition. We evaluated the impact of global 30% maternal nutrient reduction (MNR) on early fetal baboon brain maturation. MNR induced major cerebral developmental disturbances without fetal growth restriction or marked maternal weight reduction. Mechanisms evaluated included neurotrophic factor suppression, cell proliferation and cell death imbalance, impaired glial maturation and neuronal process formation, down-regulation of gene ontological pathways and related gene products, and up-regulated transcription of cerebral catabolism. Contrary to the known benefits from this degree of dietary reduction on life span, MNR in pregnancy compromises structural fetal cerebral development, potentially having an impact on brain function throughout life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.