ArticleThe Journal of infectious diseases2011
Staphylococcal enterotoxin B causes proliferation of sensory C-fibers and subsequent enhancement of neurogenic inflammation in rat skin.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- A Nationwide, Population-based Cohort Study on Potential Autoimmune Association of Ménière Disease to Atopy and Vitiligo.Scientific reports · 2019Article
- Case-control study of mandibular canal branching and tooth-related inflammatory lesions.Oral radiology · 2018Article
- Mandibular canal branching assessed with cone beam computed tomography.La Radiologia medica · 2018Article
- Antidromic neurogenic activity and cutaneous bacterial flora.Seminars in immunopathology · 2018Review
- Neurogenic markers of the inflammatory process in atopic dermatitis: relation to the severity and pruritus.Postepy dermatologii i alergologii · 2013Article
- Tissue preparation and immunostaining of mouse sensory nerve fibers innervating skin and limb bones.Journal of visualized experiments : JoVE · 2012Article
- Atopic dermatitis: allergic dermatitis or neuroimmune dermatitis?Anais brasileiros de dermatologiaReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcal enterotoxin B (SEB) may be associated with the exacerbation of atopic dermatitis. We investigated whether SEB causes proliferation of sensory C-fibers and subsequent enhancement of plasma leakage induced by sensorineural stimulation in rat skin.
methodsSEB was applied intracutaneously to the abdomen of preweaning and adult rats. Evans blue dye leakage into the skin induced by topical 10% formalin was measured as an index of neurogenic skin vascular permeability. Local expression of substance P, tachykinin NK1 receptors, and nerve growth factor was assessed immunohistochemically. In addition, we assessed the effects of topical tacrolimus on these skin responses induced by SEB.
resultsIncreased neurogenic skin plasma leakage was seen 7 days after SEB treatment in 2 different age groups. Innervation of substance P-immunoreactive nerves and expression of tachykinin NK1 receptors and nerve growth factor were also promoted by SEB, peaking at 7 days, 7 days, and 56 h after SEB treatment, respectively. Tacrolimus markedly inhibited these skin changes.
conclusionsSEB increased the innervation of sensory C-fibers and tachykinin NK1 receptors in rat skin, probably because of upregulated production of neurotrophins, including nerve growth factor, leading to enhancement of neurogenic skin inflammation. T cell activation induced by SEB may initiate these changes.
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