ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Self-organized patterns of airway narrowing.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Self-organized ventilation defects in asthma: insights and open-source implementation of the Venegas-Winkler model.Royal Society open science · 2026Article
- Mapping airway smooth muscle remodellingERJ open research · 2026Article
- Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma.Annals of translational medicine · 2022Article
- Structure and function of small airways in asthma patients revisited.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Dynamic airway constriction in rats: heterogeneity and response to deep inspiration.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm.Nature biomedical engineering · 2019Article
- Airway Transmural Pressures in an Airway Tree During Bronchoconstriction in Asthma.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- MATHEMATICAL MODELING OF VENTILATION DEFECTS IN ASTHMA.Drug discovery today. Disease models · 2015Article
- Effects of airway tree asymmetry on the emergence and spatial persistence of ventilation defects.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Mechanical interactions between adjacent airways in the lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Mechanical correlates of dyspnea in bronchial asthma.Physiological reports · 2013Article
- Dilatation of the constricted human airway by tidal expansion of lung parenchyma.American journal of respiratory and critical care medicine · 2012Article
- Continuum vs. spring network models of airway-parenchymal interdependence.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- The importance of synergy between deep inspirations and fluidization in reversing airway closure.PloS one · 2012Article
- Issues determining direct airways hyperresponsiveness in mice.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The behavior of respiratory diseases such as asthma and COPD may involve complicated interactions among multiple factors. Theoretical and experimental data suggest that interdependence among the airways of the bronchial tree leads to the emergence of self-organized patterns of airway narrowing, ventilation defects, and other phenomena when a tipping point is passed. Additionally, evidence from several studies shows that the behavior of an isolated airway is different from an identical airway embedded in the bronchial tree so that experimental results of isolated elements such as airways, airway smooth muscle, or inflammatory pathways may not explain the whole organ behavior. However, there may be factors in the isolated elements that can dramatically change the complex system's behavior. More effective strategies for prevention or recovery from a disease, such as asthma, will depend on our progress in identifying and understanding the essential parts of the self-organized behavior that is involved.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.