Evidence map›Paper›PMID 21252053›Full record

Trial reportJournal of the American Medical Informatics Association : JAMIA

Evaluation of computer-generated reminders to improve CD4 laboratory monitoring in sub-Saharan Africa: a prospective comparative study.

Martin C Were, Changyu Shen, William M Tierney, Joseph J Mamlin, Paul G Biondich, Xiaochun Li, Sylvester Kimaiyo, Burke W Mamlin

Abstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  11. Better adherence to pre-antiretroviral therapy guidelines after implementing an electronic medical record system in rural Kenyan HIV clinics: a multicenter pre-post study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015
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  15. Electronic health records-driven phenotyping: challenges, recent advances, and perspectives.Journal of the American Medical Informatics Association : JAMIA · 2013
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  18. Sensitivity analysis for causal inference using inverse probability weighting.Biometrical journal. Biometrische Zeitschrift · 2011
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martin C WereIndiana University School of Medicine, Indianapolis, Indiana, USA. mwere@regenstrief.org
Changyu Shen
William M Tierney
Joseph J Mamlin
Paul G Biondich
Xiaochun Li
Sylvester Kimaiyo
Burke W Mamlin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLittle evidence exists on effective interventions to integrate HIV-care guidelines into practices within developing countries. This study tested the hypothesis that clinical summaries with computer-generated reminders could improve clinicians' compliance with CD4 testing guidelines in the resource-limited setting of sub-Saharan Africa.

designA prospective comparative study of two randomly selected outpatient adult HIV clinics in western Kenya. Printed summaries with reminders for overdue CD4 tests were made available to clinicians in the intervention clinic but not in the control clinic. MEASUREMENTS: Changes in order rates for overdue CD4 tests were compared between and within the two clinics.

resultsThe computerized reminder system identified 717 encounters (21%) with overdue CD4 tests. Analysis by study assignment (regardless of summaries being printed or not) revealed that with computer-generated reminders, CD4 order rates were significantly higher in the intervention clinic compared to the control clinic (53% vs 38%, OR = 1.80, CI 1.34 to 2.42, p < 0.0001). When comparison was restricted to encounters where summaries with reminders were printed, order rates in intervention clinic were even higher (63%). The intervention clinic increased CD4 ordering from 42% before reminders to 63% with reminders (50% increase, OR = 2.32, CI 1.67 to 3.22, p < 0.0001), compared to control clinic with only 8% increase from prestudy baseline (CI 0.83 to 1.46, p = 0.51). Limitations Evaluation was conducted at two clinics in a single institution.

conclusionsClinical summaries with computer-generated reminders significantly improved clinician compliance with CD4 testing guidelines in the resource-limited setting of sub-Saharan Africa. This technology can have broad applicability to improve quality of HIV care in these settings.

Indexed as

CD4 Lymphocyte CountDecision Support Systems, ClinicalGuideline AdherenceReminder SystemsAdultElectronic Health RecordsFemaleHIV InfectionsHumansKenyaLinear ModelsMaleProspective Studies

Identifiers

PMID21252053
PMCPMC3116261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.