ArticleEnvironmental health : a global access science source2011
Fungal exposure in homes of patients with sarcoidosis - an environmental exposure study.
Article in Environmental health : a global access science source, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sarcoidosis as an Autoimmune Disease.Frontiers in immunology · 2019Pooled it
- Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis.International journal of environmental research and public health · 2018Trial
- Sarcoidosis treatment with antifungal medication: a follow-up.Pulmonary medicine · 2014Trial
- Particles exposures and sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Residential fungal β-(1,3)-D-glucan exposure is associated with decreased pulmonary function in fibrotic pulmonary sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Targeting the mycobiome in sarcoidosis.Frontiers in medicine · 2025Article
- A framework for exclusion of alternative diagnoses in sarcoidosis.Journal of autoimmunity · 2024Review
- AWMF mold guideline "Medical clinical diagnostics for indoor mold exposure" - Update 2023 AWMF Register No. 161/001.Allergologie select · 2024Article
- Identification of Environmental Exposures Associated with Risk of Sarcoidosis in African Americans.Annals of the American Thoracic Society · 2023Article
- Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants.Life (Basel, Switzerland) · 2023Review
- Mind the gap between non-activated (non-aggressive) and activated (aggressive) indoor fungal testing: impact of pre-sampling environmental settings on indoor air readings.UCL open. Environment · 2023Article
- Exploring Occupational, Recreational, and Environmental Associations in Patients With Clinically Manifest Cardiac Sarcoidosis.CJC open · 2020Article
- Normal background levels of air and surface mould reserve in English residential building stock: a preliminary study towards benchmarks based on NAHA measurements.UCL open. Environment · 2020Article
- Comparison of serum interleukin-10 level of fungal exposure among patients with pulmonary sarcoidosis and healthy people.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- Cytotoxic and Inflammatory Potential of Air Samples from Occupational Settings with Exposure to Organic Dust.Toxics · 2017Article
- β-glucan in the lymph nodes in sarcoidosis and in Kveim-Siltzbach test reagent.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2017Article
- Fungal cell wall agents and bacterial lipopolysaccharide in organic dust as possible risk factors for pulmonary sarcoidosis.Journal of occupational medicine and toxicology (London, England) · 2016Article
- An Evolutionary-Based Framework for Analyzing Mold and Dampness-Associated Symptoms in DMHS.Frontiers in immunology · 2016Article
- Interleukin-12 family cytokines and sarcoidosis.Frontiers in pharmacology · 2014Review
- Fungal exposure and low levels of IL-10 in patients with sarcoidosis.Pulmonary medicine · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence that exposure to moulds (fungi) may influence the development of sarcoidosis. To assess the influence of the environmental exposure, a study was undertaken to determine the exposure to fungi in homes of subjects with sarcoidosis.
methodsSubjects were patients with clinically established sarcoidosis recruited during the period September 2007 till June 2010. Of these 55 were newly diagnosed and currently under treatment for less than one year, 25 had been treated and had no recurrence and 27 had been treated but had recurrence of the disease. Controls were healthy subjects without any respiratory symptoms (n = 30). Samples of air (about 2.5 m3) were taken in the bedroom of the subjects using a portable pump and cellulose ester filters. The filters were analysed for the content of the enzyme N-acetylhexosaminidase (NAHA) as a marker of fungal cell biomass, using a specific substrate and a fluorescent technique and expressed as NAHA units (U)/m3.
resultsCompared to controls, subjects undergoing treatment of the disease (newly diagnosed or with recurrence) had significantly higher activities of NAHA in their homes than controls (33.6 and 39.9 vs 10.0 U/m3, p < 0.001 and <0.001). Among controls only 5 out of 30 subjects had levels of NAHA above the second quartile value (14 U/m3). In homes of subjects with newly diagnosed disease with treatment less than one year, values above 14 NAHA U/m3 were found among 35 out of 55 and among those with recurrent disease among 18 out of 27.
conclusionsThe higher activities of NAHA enzyme found in homes of subjects with active and recurrent sarcoidosis suggest that exposure to fungi is related to the risk of sarcoidosis. Further environmental studies to assess the importance of this exposure for subjects with sarcoidosis are warranted. The results suggest that remedial actions in homes with high levels of fungi may be justified.
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