Evidence map›Paper›PMID 21251049›Full record

ReviewClinical and experimental pharmacology & physiology2012

Renal inflammation, autoimmunity and salt-sensitive hypertension.

Bernardo Rodríguez-Iturbe, Martha Franco, Edilia Tapia, Yasmir Quiroz, Richard J Johnson

Abstract readReview
In one paragraph

Review in Clinical and experimental pharmacology & physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Emerging Role of the Inflammasome and Pyroptosis in Hypertension.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Genetic disruption ofAmerican journal of physiology. Renal physiology · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. The protective role of vitamin D on the heart and the kidney.Therapeutic advances in cardiovascular disease · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Bernardo Rodríguez-IturbeRenal Service, University Hospital, University of Zulia and Venezuelan Institute of Scientific Research-Zulia, Maracaibo, Estado Zulia, Venezuela. brodrigueziturbe@gmail.com
Martha Franco
Edilia Tapia
Yasmir Quiroz
Richard J Johnson
Instituto Nacional de Cardiología · MXUniversity of Zulia · VEUniversity of Colorado Anschutz Medical Campus · US

Funding

Role of Uric Acid in Hypertension and Renal DiseaseR01HL068607 · NHLBI · UNIVERSITY OF FLORIDA · PI JOHNSON, RICHARD JOSEPH · 2002 to 2011
$3.5M
NHLBI NIH HHS HL-6860NHLBI NIH HHS R01 HL068607
6 · The paper itself

Abstract

1. The present article reviews the role of immune-competent cells infiltrating the kidney and their association with oxidative stress and renal angiotensin activity in the development of salt-sensitive hypertension. 2. We discuss changes in the pressure-natriuresis relationship resulting from renal inflammation and its improvement resulting from immunosuppressive treatment. 3. The potential role of T-cell-driven reactivity in sustaining the renal inflammation is examined in the light of accumulating evidence of autoimmune mechanisms in experimental and clinical hypertension.

Indexed as

AutoimmunityAnimalsAutoantibodiesAutoimmune DiseasesChaperonin 60Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHumansHypertensionKidney TubulesMacrophagesMitochondrial ProteinsNatriuresisNephritisSodium Chloride, DietaryT-LymphocytesAutoantibodiesChaperonin 60Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHSPD1 protein, humanMitochondrial ProteinsSodium Chloride, Dietary

Identifiers

PMID21251049
PMCPMC3137657
OpenAlexW1953447169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.