ReviewJournal of cutaneous pathology2011
Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus.
Review in Journal of cutaneous pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 80 citations in OpenAlex.
- Paraneoplastic Motor Neuropathy in Nodular Sclerosis Hodgkin's Lymphoma: Case Report.Case reports in hematology · 2026Article
- Management of Trichodysplasia Spinulosa in a Pediatric Kidney Transplant Patient With Topical Cidofovir and Oral Leflunomide.Pediatric transplantation · 2025Article
- [Human polyomavirus-associated skin diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022Review
- Sustained Trichodysplasia Spinulosa Polyomavirus Viremia Illustrating a Primary Disseminated Infection in a Kidney Transplant Recipient.Microorganisms · 2021Article
- Article
- Trichodysplasia spinulosa: a comprehensive review of the disease and its treatment.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Review
- Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.PLoS pathogens · 2021Article
- Photodynamic therapy for the treatment of trichodysplasia spinulosa in an Asian renal transplant recipient: A case report and review of literature.JAAD case reports · 2021Article
- Facial Spinulate Demodicosis.Clinical, cosmetic and investigational dermatology · 2021Article
- Trichodysplasia spinulosa in a renal transplant patient: A case report of successful treatment.SAGE open medical case reports · 2020Article
- Widespread keratosis pilaris-like eruption in an immunocompromised child.JAAD case reports · 2019Article
- The Biology and Clinical Features of Cutaneous Polyomaviruses.The Journal of investigative dermatology · 2019Review
- Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses.Journal of the American Academy of Dermatology · 2017Article
- Trichodysplasia Spinulosa in a 7-Year-Old Boy Managed Using Physical Extraction of Keratin Spicules.Pediatric dermatology · 2017Article
- Review
- Two cases of trichodysplasia spinulosa responsive to compounded topical cidofovir 3% cream.JAAD case reports · 2015Article
- Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids.PLoS pathogens · 2015Article
- Polyomaviruses and disease: is there more to know than viremia and viruria?Current opinion in organ transplantation · 2015Review
- The cause of follicular spicules in multiple myeloma.JAMA dermatology · 2015Article
- Polyomavirus-associated Trichodysplasia spinulosa involves hyperproliferation, pRB phosphorylation and upregulation of p16 and p21.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Trichodysplasia spinulosa (TS) is a folliculocentric and clinically papular dermatological disorder occurring in the setting of immunosuppression typically in association with solid organ transplantation or hematolymphoid malignancies. We report the occurrence of TS in a 7-year-old girl with Down syndrome and pre-B-acute lymphoblastic leukemia who was completing chemotherapy at onset. The patient's affected follicles were dilated by an expansion of a dystrophic follicular inner root sheath cell population displaying enlarged trichohyaline cytoplasmic granules and progressing centrally to keratotic and parakeratotic debris, and superficially demonstrating some diminutive hair shaft-like material within the keratotic spicules. Electron microscopic studies of a follicular lesion showed extracellular viral particles suggestive of a polyomavirus within the central follicular keratotic debris. DNA polymerase chain reaction (PCR) and gene sequencing studies, performed on the tissue of the microscopic slide and paraffin block, for the recently identified TS-associated polyomavirus (TSPyV) resulted as positive for TSPyV. PCR for the Merkel cell polyomavirus was negative. To date, this case is unique in representing the first case of TS confirmed by electron microscopy in which a related viral pathogen has been molecularly identified. An additional 19 reported cases classifiable as TS are tabulated and reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.