ArticleAnalytical chemistry2011
Application of photonic crystal enhanced fluorescence to cancer biomarker microarrays.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 103 citations in OpenAlex.
- Photonic crystal enhanced fluorescence using a hybrid hexagonal boron nitride spacer and plasmonic gold cryosoret cavity.Nanoscale · 2025Article
- Blood Biomarker Detection Using Integrated Microfluidics with Optical Label-Free Biosensor.Sensors (Basel, Switzerland) · 2024Article
- Bio-inspired optical structures for enhancing luminescence.Exploration (Beijing, China) · 2023Review
- Multi-analyte sensing strategies towards wearable and intelligent devices.Chemical science · 2022Review
- Fluorescence Coupling to Internal Modes of 1D Photonic Crystals Characterized by Back Focal Plane Imaging.Journal of optics (2010) · 2021Article
- Using protein microarray to identify and evaluate autoantibodies to tumor-associated antigens in ovarian cancer.Cancer science · 2021Article
- Biomimetic Nanostructure Platform for Cancer Diagnosis Based on Tumor Biomarkers.Frontiers in bioengineering and biotechnology · 2021Review
- Activate capture and digital counting (AC + DC) assay for protein biomarker detection integrated with a self-powered microfluidic cartridge.Lab on a chip · 2019Article
- An Automated Microfluidic Assay for Photonic Crystal Enhanced Detection and Analysis of an Antiviral Antibody Cancer Biomarker in Serum.IEEE sensors journal · 2018Article
- CMOS-Compatible Fabrication for Photonic Crystal-Based Nanofluidic Structure.Nanoscale research letters · 2017Article
- Bloch Surface Wave-Coupled Emission at Ultra-Violet Wavelengths.The journal of physical chemistry. C, Nanomaterials and interfaces · 2016Article
- Plasmonic nanoparticles tuned thermal sensitive photonic polymer for biomimetic chameleon.Scientific reports · 2016Article
- Application of photonic crystal enhanced fluorescence to detection of low serum concentrations of human IgE antibodies specific for a purified cat allergen (Fel D1).Biosensors & bioelectronics · 2016Article
- High sensitivity automated multiplexed immunoassays using photonic crystal enhanced fluorescence microfluidic system.Biosensors & bioelectronics · 2015Article
- Direct detection of transcription factors in cotyledons during seedling development using sensitive silicon-substrate photonic crystal protein arrays.Plant physiology · 2015Article
- Two-dimensional photonic crystals for sensitive microscale chemical and biochemical sensing.Lab on a chip · 2015Review
- Article
- On-chip detection of a single nucleotide polymorphism without polymerase amplification.Nano research · 2014Article
- A compact immunoassay platform based on a multicapillary glass plate.Sensors (Basel, Switzerland) · 2014Article
- Photonic crystal enhancement of a homogeneous fluorescent assay using submicron fluid channels fabricated by E-jet patterning.Journal of biophotonics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
We report on the use of photonic crystal surfaces as a high-sensitivity platform for detection of a panel of cancer biomarkers in a protein microarray format. The photonic crystal surface is designed to provide an optical resonance at the excitation wavelength of cyanine-5 (Cy5), thus providing an increase in fluorescent intensity for Cy5-labeled analytes measured with a confocal microarray scanner, compared to a glass surface. The sandwich enzyme-linked immunosorbent assay (ELISA) is undertaken on a microarray platform to undertake a simultaneous, multiplex analysis of 24 antigens on a single chip. Our results show that the resonant excitation effect increases the signal-to-noise ratio by 3.8- to 6.6-fold, resulting in a decrease in detection limits of 6-89%, with the exact enhancement dependent upon the antibody-antigen interaction. Dose-response characterization of the photonic crystal antibody microarrays shows the capability to detect common cancer biomarkers in the <2 pg/mL concentration range within a mixed sample.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.